| Literature DB >> 1090304 |
Abstract
The antibiotic steffimycin B binds to double-stranded DNA as evidenced by difference spectroscopy and an increase of the thermal stability of DNA in the presence of the antibiotic. Salmon sperm DNA-steffimycin B complexes show a drastic decrease in template activity for Escherichia coli DNA polymerase I but not for DNA-idrected RNA polymerase. The differences in template properties of poly[d(A-T)] and poly (dG) - poly(dC)-antibiotic complexes,respectively, for DNA polymerase I and RNA polymerase suggest that the antibiotic interacts primarily with adenine or thymine bases or both in double-stranded DNA.Entities:
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Year: 1975 PMID： 1090304 DOI： 10.1016/0005-2787(75)90055-6
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002