Literature DB >> 10900355

Intrathecal IgG synthesis and autoantibody-secreting cells in multiple sclerosis.

F Sellebjerg1, C V Jensen, M Christiansen.   

Abstract

We studied intrathecal IgG synthesis and autoantibody-secreting cells in 148 patients with possible onset symptoms of MS (POSMS) or clinically definite MS (CDMS). In POSMS intrathecal synthesis of IgG oligoclonal bands and abnormalities on T2-weighted magnetic resonance imaging were associated but the former were more prevalent. The cerebrospinal fluid (CSF) leukocyte count and the number of anti-protelipid protein antibody-secreting cells in cerebrospinal fluid (CSF) correlated with disease activity in POSMS. Intrathecal IgG synthesis levels and the number of anti-myelin basic protein antibody-secreting cells in CSF correlated with disease activity in CDMS. Our results support recent reports of pathogenetic heterogeneity and a pathogenetic role of the antibody response in MS.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10900355     DOI： 10.1016/s0165-5728(00)00292-7

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  8 in total

1.  Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection.

Authors:  Christopher Harp; Jane Lee; Doris Lambracht-Washington; Elizabeth Cameron; Gregory Olsen; Elliot Frohman; Michael Racke; Nancy Monson
Journal:  J Neuroimmunol       Date:  2006-12-13       Impact factor: 3.478

2.  DNA methylation in repetitive elements and Alzheimer disease.

Authors:  V Bollati; D Galimberti; L Pergoli; E Dalla Valle; F Barretta; F Cortini; E Scarpini; P A Bertazzi; A Baccarelli
Journal:  Brain Behav Immun       Date:  2011-02-03       Impact factor: 7.217

3.  Role of Helical Structure in MBP Immunodominant Peptides for Efficient IgM Antibody Recognition in Multiple Sclerosis.

Authors:  Agnieszka Staśkiewicz; Michael Quagliata; Feliciana Real-Fernandez; Francesca Nuti; Roberta Lanzillo; Vincenzo Brescia-Morra; Hendrik Rusche; Michal Jewginski; Alfonso Carotenuto; Diego Brancaccio; Rina Aharoni; Ruth Arnon; Paolo Rovero; Rafal Latajka; Anna Maria Papini
Journal:  Front Chem       Date:  2022-06-20       Impact factor: 5.545

4.  Autoantibodies to myelin basic protein (MBP) in healthy individuals and in patients with multiple sclerosis: a role in regulating cytokine responses to MBP.

Authors:  Chris J Hedegaard; Ning Chen; Finn Sellebjerg; Per Soelberg Sørensen; R Graham Q Leslie; Klaus Bendtzen; Claus H Nielsen
Journal:  Immunology       Date:  2008-12-18       Impact factor: 7.397

5.  Expansion of antibody reactivity in the cerebrospinal fluid of multiple sclerosis patients - follow-up and clinical implications.

Authors:  Hela-Felicitas Petereit; Dirk Reske
Journal:  Cerebrospinal Fluid Res       Date:  2005-06-27

6.  A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients.

Authors:  Ann J Ligocki; Jacqueline R Rivas; William H Rounds; Alyssa A Guzman; Min Li; Melania Spadaro; Lauren Lahey; Ding Chen; Paul M Henson; Donna Graves; Benjamin M Greenberg; Elliot M Frohman; E Sally Ward; William Robinson; Edgar Meinl; Charles L White; Ann M Stowe; Nancy L Monson
Journal:  ASN Neuro       Date:  2015-10-21       Impact factor: 4.146

Review 7.  The Cerebrospinal Fluid in Multiple Sclerosis.

Authors:  Florian Deisenhammer; Henrik Zetterberg; Brit Fitzner; Uwe K Zettl
Journal:  Front Immunol       Date:  2019-04-12       Impact factor: 7.561

8.  Anti-Myelin Proteolipid Protein Peptide Monoclonal Antibodies Recognize Cell Surface Proteins on Developing Neurons and Inhibit Their Differentiation.

Authors:  Raymond A Sobel; Mary Jane Eaton; Prajakta Dilip Jaju; Eugene Lowry; Julian R Hinojoza
Journal:  J Neuropathol Exp Neurol       Date:  2019-09-01       Impact factor: 3.685
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.