Literature DB >> 10900331

Regulation of cell cycle proteins by TNF-alpha and TGF-beta in cells of oligodendroglial lineage.

C Yu1, M Takeda, B Soliven.   

Abstract

Proliferation and apoptosis are two dynamic, interrelated processes that are regulated by growth factors and cytokines. We investigated the effects of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) on apoptosis and regulation of cell cycle proteins in OLG lineage cells. We found that: (1) both cytokines enhanced apoptosis in neonatal pre-OLGs but only TNFalpha-mediated apoptosis persisted in the presence of a mitogen, fibroblast growth factor (FGF); (2) cell cycle proteins such as p21(waf1/cip1), p27(kip1), cyclin D1 and PCNA were differentially regulated by TNF-alpha and TGF-beta. We conclude that differential modulation of cell cycle proteins by TNF-alpha and TGF-beta contributes to the diversity of their biological effects in OLG lineage cells.

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Year:  2000        PMID： 10900331     DOI： 10.1016/s0165-5728(99)00278-7

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  10 in total

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Review 2.  Oligodendrocyte fate after spinal cord injury.

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4.  N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo.

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6.  Differential proliferation rhythm of neural progenitor and oligodendrocyte precursor cells in the young adult hippocampus.

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7.  Molecular mechanisms of neonatal brain injury.

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Journal:  Neurol Res Int       Date:  2012-01-26

Review 8.  Cell Death in the Developing Brain after Hypoxia-Ischemia.

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Journal:  Front Cell Neurosci       Date:  2017-08-23       Impact factor: 5.505

9.  Differential expression and role of p21cip/waf1 and p27kip1 in TNF-alpha-induced inhibition of proliferation in human glioma cells.

Authors:  Pabbisetty Sudheer Kumar; Anjali Shiras; Gowry Das; Jayashree C Jagtap; Vandna Prasad; Padma Shastry
Journal:  Mol Cancer       Date:  2007-06-12       Impact factor: 27.401

Review 10.  Duality of Interactions Between TGF-β and TNF-α During Tumor Formation.

Authors:  Zhi-Wei Liu; Yi-Ming Zhang; Li-Ying Zhang; Ting Zhou; Yang-Yang Li; Gu-Cheng Zhou; Zhi-Ming Miao; Ming Shang; Jin-Peng He; Nan- Ding; Yong-Qi Liu
Journal:  Front Immunol       Date:  2022-01-05       Impact factor: 7.561
  10 in total

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