Literature DB >> 10898915

5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait.

S Blairy1, I Massat, L Staner, O Le Bon, S Van Gestel, C Van Broeckhoven, C Hilger, F Hentges, D Souery, J Mendlewicz.   

Abstract

The purpose [corrected] of this study was to investigate the relationship between bipolar disorder and the harm avoidance personality trait (HA), and the genetic contribution of the polymorphic DNA variation T102C in exon 1 of 5-HTR2a (chromosome 13q14-21) in bipolar disorder and HA personality trait. Forty bipolar patients and 89 normal subjects completed the TPQ questionnaire and were genotyped for 5-HT2a. Bipolar patients scored higher than normal subjects on the HA dimension. However, no contribution of the 5-HTR2a polymorphism on the bipolar disorder or on the HA personality trait emerged. Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect.

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Year:  2000        PMID： 10898915     DOI： 10.1002/1096-8628(20000612)96:3<360::aid-ajmg24>3.0.co;2-e

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  7 in total

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2.  Association between the -1438G/A and T102C polymorphisms of 5-HT2A receptor gene and obstructive sleep apnea: a meta-analysis.

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6.  Comparative Study of Personality Traits in Patients with Bipolar I and II Disorder from the Five-Factor Model Perspective.

Authors:  Byungsu Kim; Jong-Han Lim; Seong Yoon Kim; Yeon Ho Joo
Journal:  Psychiatry Investig       Date:  2012-11-12       Impact factor: 2.505

7.  The influence of the Val158Met catechol-O-methyltransferase polymorphism on the personality traits of bipolar patients.

Authors:  Wendy Dávila; Nieves Basterreche; Aurora Arrue; María I Zamalloa; Estíbaliz Gordo; Ricardo Dávila; Miguel A González-Torres; Mercedes Zumárraga
Journal:  PLoS One       Date:  2013-04-30       Impact factor: 3.240
  7 in total

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