| Literature DB >> 10898081 |
M Ramadas1, W Paul, K J Dileep, Y Anitha, C P Sharma.
Abstract
An oral formulation based on liposome encapsulated alginate-chitosan gel capsules was developed for insulin delivery for the treatment of diabetes. Liposome encapsulation helped to increase the encapsulation efficiency of insulin in alginate-chitosan capsules. This formulation delivers insulin in the neutral environment of the intestine, by-passing the acidic media in the stomach, with increased drug absorption and bioavailability. Oral administration of this formulation was found to reduce blood glucose levels when tested in diabetic rats.Entities:
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Year: 2000 PMID： 10898081 DOI： 10.1080/026520400405660
Source DB: PubMed Journal: J Microencapsul ISSN： 0265-2048 Impact factor: 3.142