Literature DB >> 1089729

Immune response to liposomal model membranes: restricted IgM and IgG anti-dinitrophenyl antibodies produced in guinea pigs.

K Uemura, J L Claflin, J M Davie, S C Kinsky.   

Abstract

Guinea pigs were immunized with liposomal model membranes actively sensitized with 2,4-dinitrophenyl-aminocaproylphosphatidyl-ethanolamine. The immune response was characterized by the formation of both IgM and IgG anti-DNP plaque-forming cells (PFC) which paralleled the appearance of anti-DNP antibodies in the serum. Plaque inhibition by DNP-lysine indicated that the PFC produced after liposomal immunization fell in a much narrower range of avidity groups than the PFC obtained after immunization with DNP-albumin and, in this regard, resembled MOPC 315. The restricted nature of the serum IgG anti-DNP antibodies was confirmed by isoelectric focusing and revealed the expression of a limited number of clones in all cases.

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Year:  1975        PMID： 1089729

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  6 in total

1.  Stimulation and inhibition of anti-hapten responses in guinea pigs immunized with hybrid liposomes.

Authors:  N Kochibe; R A Nicolotti; J M Davie; S C Kinsky
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

2.  Characterization of immunogenic properties of haptenated liposomal model membranes in mice. I. Thymus independence of the antigen.

Authors:  A J van Houte; H Snippe; J M Willers
Journal:  Immunology       Date:  1979-06       Impact factor: 7.397

3.  Immune response of rabbits to lipid A: influence of immunogen preparation and distribution of various lipid A specificities.

Authors:  H M Kuhn
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

4.  Clonal dominance. I. Restricted nature of the IgM antibody response to group A streptococcal carbohydrate in mice.

Authors:  D E Briles; J M Davie
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307

5.  Immunochemical studies of conjugates of isomaltosyl oligosaccharides to lipid. I. Antigenicity of the glycolipids and the production of specific antibodies in rabbits.

Authors:  C Wood; E A Kabat
Journal:  J Exp Med       Date:  1981-08-01       Impact factor: 14.307

6.  Lipid vesicle-cell interactions. III. Introduction of a new antigenic determinant into erythrocyte membranes.

Authors:  F J Martin; R C MacDonald
Journal:  J Cell Biol       Date:  1976-09       Impact factor: 10.539
  6 in total

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