Literature DB >> 10897264

Hypothermia, coagulopathy, and acidosis.

V A Eddy1, J A Morris, D C Cullinane.   

Abstract

The management of patients requiring a damage control approach taxes the abilities of the best equipped trauma center. These patients present with severe metabolic abnormalities, most notably characterized by a deadly triad of hypothermia, coagulopathy, and acidosis. Using volumetric, oxymetric pulmonary artery catheters, hypothermia and any ongoing cardiovascular abnormalities can be identified quickly and treatment can be monitored. External, forced air rewarming is a valuable technique in treating the patient with hypothermia, as are more invasive modalities, including body cavity lavage. Although there is no shotgun approach to blood component transfusion therapy, the coagulopathy shown by these patients has a time course that is more rapid than stat laboratories can presently keep up with. Given the fulminant nature of this coagulopathy, the authors feel justified in empirically initiating platelet and plasma or cryoprecipitate transfusion on identification of visible coagulopathy. The willingness of trauma surgeons to push the envelope in treating these most severely afflicted patients has allowed patients who once would have certainly died to lead meaningful lives.

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Year:  2000        PMID: 10897264     DOI: 10.1016/s0039-6109(05)70099-2

Source DB:  PubMed          Journal:  Surg Clin North Am        ISSN: 0039-6109            Impact factor:   2.741


  27 in total

1.  Implementation of Trauma Center and Massive Transfusion Protocol Improves Outcomes for Major Trauma Patients: A Study at a Single Institution in Korea.

Authors:  Kyungjin Hwang; Junsik Kwon; Jayun Cho; Yunjung Heo; John Cook-Jong Lee; Kyoungwon Jung
Journal:  World J Surg       Date:  2018-07       Impact factor: 3.352

2.  Eleven years of liver trauma: the Scottish experience.

Authors:  John M Scollay; Diana Beard; Rik Smith; Dermot McKeown; O James Garden; Rowan Parks
Journal:  World J Surg       Date:  2005-06       Impact factor: 3.352

3.  Admission hypo- or hyperthermia and survival after trauma in civilian and military environments.

Authors:  Charles E Wade; José Salinas; Brian J Eastridge; John G McManus; John B Holcomb
Journal:  Int J Emerg Med       Date:  2011-06-23

4.  Pathophysiology of early trauma-induced coagulopathy: emerging evidence for hemodilution and coagulation factor depletion.

Authors:  Beth H Shaz; Anne M Winkler; Adelbert B James; Christopher D Hillyer; Jana B MacLeod
Journal:  J Trauma       Date:  2011-06

Review 5.  Transfusion management of trauma patients.

Authors:  Beth H Shaz; Christopher J Dente; Robert S Harris; Jana B MacLeod; Christopher D Hillyer
Journal:  Anesth Analg       Date:  2009-06       Impact factor: 5.108

6.  Prolonged mild therapeutic hypothermia versus fever control with tight hemodynamic monitoring and slow rewarming in patients with severe traumatic brain injury: a randomized controlled trial.

Authors:  Tsuyoshi Maekawa; Susumu Yamashita; Seigo Nagao; Nariyuki Hayashi; Yasuo Ohashi
Journal:  J Neurotrauma       Date:  2015-01-08       Impact factor: 5.269

7.  Management of bleeding following major trauma: an updated European guideline.

Authors:  Rolf Rossaint; Bertil Bouillon; Vladimir Cerny; Timothy J Coats; Jacques Duranteau; Enrique Fernández-Mondéjar; Beverley J Hunt; Radko Komadina; Giuseppe Nardi; Edmund Neugebauer; Yves Ozier; Louis Riddez; Arthur Schultz; Philip F Stahel; Jean-Louis Vincent; Donat R Spahn
Journal:  Crit Care       Date:  2010-04-06       Impact factor: 9.097

Review 8.  Management of bleeding and coagulopathy following major trauma: an updated European guideline.

Authors:  Donat R Spahn; Bertil Bouillon; Vladimir Cerny; Timothy J Coats; Jacques Duranteau; Enrique Fernández-Mondéjar; Daniela Filipescu; Beverley J Hunt; Radko Komadina; Giuseppe Nardi; Edmund Neugebauer; Yves Ozier; Louis Riddez; Arthur Schultz; Jean-Louis Vincent; Rolf Rossaint
Journal:  Crit Care       Date:  2013-04-19       Impact factor: 9.097

9.  Hemolysis with rapid transfusion systems in the trauma setting.

Authors:  Peter Kim; Ian Chin-Yee; Kathleen Eckert; Richard A Malthaner; Daryl K Gray
Journal:  Can J Surg       Date:  2004-08       Impact factor: 2.089

10.  Therapeutic peritoneal lavage with warm saline solution as an option for a critical hypothermic trauma patient.

Authors:  Thomas Freude; Sonja Gillen; Sabrina Ehnert; Andreas Nüssler; Ulrich Stöckle; Natascha Charalambakis; Stefan Döbele; Stefan Pscherer
Journal:  Wien Klin Wochenschr       Date:  2013-11-19       Impact factor: 1.704

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