Literature DB >> 1089709

Subepidermal deposition of immunoglobulin in NZB/NZW F hybrid mice.

J N Gilliam, E R Hurd, M Ziff.   

Abstract

The dermal-epidermal junction of NZB/NZW F1 hybrid mice is a site of immunoglobulin (Ig) deposition. This produces a fluorescent band which is very similar to that seen in the skin of patients with systemic lupus erythematosus. The deposition of Ig in the mouse skin is first observed at six months of age and increases in frequency thereafter. After an initial lag of 1 to 2 months, it parallels the age-related deposition of Ig in the kidney. The observed temporal relationship between glomerular and cutaneous Ig deposition supports the concept that the presence of immunoglobulin in the skin is highly indicative of the presence of immune complexes in the kidney.

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Year:  1975        PMID： 1089709

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  11 in total

1.  Genetic studies on the skin lupus band test in New Zealand mice.

Authors:  F Furukawa; N Maruyama; H Yoshida; Y Hamashima; S Hirose; T Shirai
Journal:  Clin Exp Immunol       Date:  1985-01       Impact factor: 4.330

2.  Quantitative studies of immunoglobulin deposition in the kidney, glomerular cell proliferation and glomerulosclerosis in NZB/NZW F1 hybrid mice.

Authors:  E R Hurd; M Ziff
Journal:  Clin Exp Immunol       Date:  1977-02       Impact factor: 4.330

Review 3.  Immunologically mediated epidermal cell injury.

Authors:  R D Sontheimer; J N Gilliam
Journal:  Springer Semin Immunopathol       Date:  1981-06

4.  Immune complexes in skin of NZB/NZW mice.

Authors:  V M Sommer; U H Rudofsky; A E Gabrielsen
Journal:  Clin Exp Immunol       Date:  1975-12       Impact factor: 4.330

5.  James Neil Gilliam, MD-the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease.

Authors:  Richard D Sontheimer
Journal:  Ann Transl Med       Date:  2018-06

6.  Immunoglobulin classes in skin basement membrane in systemic lupus erythematosus: clinical significance and comparison with classes of serum anti-DNA antibodies.

Authors:  B Bresnihan; G M Hale; C C Bunn; G R Hughes
Journal:  Ann Rheum Dis       Date:  1979-08       Impact factor: 19.103

7.  Differences in the occurrence of hypertension among (NZB X NZW)F1, MRL-lpr, and BXSB mice with lupus nephritis.

Authors:  U H Rudofsky; R L Dilwith; J B Roths; D A Lawrence; V E Kelley; A M Magro
Journal:  Am J Pathol       Date:  1984-07       Impact factor: 4.307

8.  The differential effects of cyclophosphamide and 6-mercaptopurine on the renal disease and skin immunoglobulin deposits of the NZB-NZW F1 hybrid mice.

Authors:  E R Hurd; J N Gilliam; M Ziff
Journal:  Agents Actions       Date:  1976-02

9.  Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone.

Authors:  J A Lucas; S A Ahmed; M L Casey; P C MacDonald
Journal:  J Clin Invest       Date:  1985-06       Impact factor: 14.808

10.  Prevention of glomerulonephritis and prolonged survival in New Zealand Black/New Zealand White F1 hybrid mice fed an essential fatty acid-deficient diet.

Authors:  E R Hurd; J M Johnston; J R Okita; P C MacDonald; M Ziff; J W Gilliam
Journal:  J Clin Invest       Date:  1981-02       Impact factor: 14.808
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