Literature DB >> 10896127

Alkyl and alkoxycarbonyl derivatives of ginkgolide B: synthesis and biological evaluation of PAF inhibitory activity.

L Hu1, Z Chen, Y Xie, Y Jiang, H Zhen.   

Abstract

Alkyl and alkoxycarbonyl derivatives 6-24 of ginkgolide B, prepared in one step from ginkgolide B through alkylation and acylation and evaluated for their in vitro ability to inhibit the PAF-induced aggregation of rabbit platelets, show equivalent or superior activities to ginkgolide B.

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Year:  2000        PMID： 10896127     DOI： 10.1016/s0968-0896(00)00085-7

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2.

Authors:  Zheng-Yi Li; Yoon Hee Chung; Eun-Joo Shin; Duy-Khanh Dang; Ji Hoon Jeong; Sung Kwon Ko; Seung-Yeol Nah; Tae Gon Baik; Jin Hyeong Jhoo; Wei-Yi Ong; Toshitaka Nabeshima; Hyoung-Chun Kim
Journal:  J Neuroinflammation       Date:  2017-04-27       Impact factor: 8.322

2.  Design, Synthesis and Anti-Platelet Aggregation Activity Study of Ginkgolide-1,2,3-triazole Derivatives.

Authors:  Jian Cui; Le'An Hu; Wei Shi; Guozhen Cui; Xumu Zhang; Qing-Wen Zhang
Journal:  Molecules       Date:  2019-06-07       Impact factor: 4.411

3.  A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway.

Authors:  Xiao Chu; Xinxin Ci; Jiakang He; Miaomiao Wei; Xiaofeng Yang; Qingjun Cao; Hongyu Li; Shuang Guan; Yanhong Deng; Daxin Pang; Xuming Deng
Journal:  Molecules       Date:  2011-09-06       Impact factor: 4.411

4.  Optimization of the Preparation Conditions of Borneol-Modified Ginkgolide Liposomes by Response Surface Methodology and Study of Their Blood Brain Barrier Permeability.

Authors:  Zhiyang Lv; Yuwei Yang; Jie Wang; Jing Chen; Junsong Li; Liuqing Di
Journal:  Molecules       Date:  2018-01-31       Impact factor: 4.411
  4 in total

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