L Wong1, Y F Chung, C Y Wong. 1. Department of Obstetrics and Gynaecology, Singapore General Hospital, Singapore.
Abstract
INTRODUCTION: Isolated single-duct nipple discharge is worrying and poses a surgical dilemma. Factors predicting malignancy are controversial. MATERIALS AND METHODS: Retrospective review of 92 consecutive microdochectomies for single-duct nipple discharge in a tertiary referral centre over 8 years. RESULTS: The commonest causes were ductal papilloma (52%) and fibrocystic diseases of the breast (21%). Five (5%) patients had breast carcinoma, of whom only 1 had an invasive component. The median age of these patients was 43 years (range 26 to 72 years) which was similar to median age of the whole cohort. Sixty-seven (73%) patients presented with blood-stained nipple discharge. The 5 patients with breast carcinoma had blood-stained discharge. Mammography was abnormal in 1 out of 4 patients in the carcinoma group. CONCLUSIONS: The incidence of breast carcinoma in patients presenting with isolated single-duct nipple discharge was low (5%) among Singaporean women. There was no reliable predictors of malignancy, though all patients with carcinoma presented with blood-stained discharge. Microdochectomy still remains an effective treatment for nipple discharge both for cure and diagnosis.
INTRODUCTION: Isolated single-duct nipple discharge is worrying and poses a surgical dilemma. Factors predicting malignancy are controversial. MATERIALS AND METHODS: Retrospective review of 92 consecutive microdochectomies for single-duct nipple discharge in a tertiary referral centre over 8 years. RESULTS: The commonest causes were ductal papilloma (52%) and fibrocystic diseases of the breast (21%). Five (5%) patients had breast carcinoma, of whom only 1 had an invasive component. The median age of these patients was 43 years (range 26 to 72 years) which was similar to median age of the whole cohort. Sixty-seven (73%) patients presented with blood-stained nipple discharge. The 5 patients with breast carcinoma had blood-stained discharge. Mammography was abnormal in 1 out of 4 patients in the carcinoma group. CONCLUSIONS: The incidence of breast carcinoma in patients presenting with isolated single-duct nipple discharge was low (5%) among Singaporean women. There was no reliable predictors of malignancy, though all patients with carcinoma presented with blood-stained discharge. Microdochectomy still remains an effective treatment for nipple discharge both for cure and diagnosis.
Authors: Robyn M Moncrief; Ritu Nayar; Leslie K Diaz; Valerie L Staradub; Monica Morrow; Seema A Khan Journal: Ann Surg Date: 2005-04 Impact factor: 12.969
Authors: Mary F Dillon; Shah R Mohd Nazri; Shaaira Nasir; Enda W McDermott; Denis Evoy; Thomas B Crotty; Niall O'Higgins; Arnold D K Hill Journal: BMC Cancer Date: 2006-06-23 Impact factor: 4.430