BACKGROUND: : Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic events, and are clinically significant in osteoarthritis and neonatal infection. METHODS: : A robust new polyclonal-monoclonal solid- phase IRMA for CRP was developed, with a range of 0.05-10.0 mg/L. RESULTS: : Plasma CRP values in general adult populations from Augsburg, Germany (2291 males and 2203 females; ages, 25-74 years) and Glasgow, Scotland (604 males and 650 females; ages, 25-64 years) were very similar. The median CRP approximately doubled with age, from approximately 1 mg/L in the youngest decade to approximately 2 mg/L in the oldest, and tended to be higher in females. CONCLUSION: : This extensive data set, the largest such study of CRP, provides valuable reference information for future clinical and epidemiological investigations.
BACKGROUND: : Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic events, and are clinically significant in osteoarthritis and neonatal infection. METHODS: : A robust new polyclonal-monoclonal solid- phase IRMA for CRP was developed, with a range of 0.05-10.0 mg/L. RESULTS: : Plasma CRP values in general adult populations from Augsburg, Germany (2291 males and 2203 females; ages, 25-74 years) and Glasgow, Scotland (604 males and 650 females; ages, 25-64 years) were very similar. The median CRP approximately doubled with age, from approximately 1 mg/L in the youngest decade to approximately 2 mg/L in the oldest, and tended to be higher in females. CONCLUSION: : This extensive data set, the largest such study of CRP, provides valuable reference information for future clinical and epidemiological investigations.
Authors: Sandi L Navarro; Elizabeth D Kantor; Xiaoling Song; Ginger L Milne; Johanna W Lampe; Mario Kratz; Emily White Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-01-11 Impact factor: 4.254
Authors: Nitin Shivappa; Andrea Schneider; James R Hébert; Wolfgang Koenig; Annette Peters; Barbara Thorand Journal: Eur J Public Health Date: 2018-02-01 Impact factor: 3.367
Authors: Bernhard M Kaess; Tonia de Las Heras Gala; Astrid Zierer; Christa Meisinger; Simone Wahl; Annette Peters; John Todd; Christian Herder; Cornelia Huth; Barbara Thorand; Wolfgang Koenig Journal: Eur J Epidemiol Date: 2017-06-05 Impact factor: 8.082
Authors: Timothy B Meier; Wayne C Drevets; T Kent Teague; Brent E Wurfel; Sven C Mueller; Jerzy Bodurka; Robert Dantzer; Jonathan Savitz Journal: Brain Behav Immun Date: 2017-09-01 Impact factor: 7.217
Authors: C Herder; J Baumert; B Thorand; W Koenig; W de Jager; C Meisinger; T Illig; S Martin; H Kolb Journal: Diabetologia Date: 2006-03-11 Impact factor: 10.122