Literature DB >> 10894163

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.

W C Yeh1, A Itie, A J Elia, M Ng, H B Shu, A Wakeham, C Mirtsos, N Suzuki, M Bonnard, D V Goeddel, T W Mak.   

Abstract

Casper (c-FLIP) associates with FADD and caspase-8 in signaling complexes downstream of death receptors like Fas. We generated Casper-deficient mice and cells and noted a duality in the physiological functions of this molecule. casper-/- embryos do not survive past day 10.5 of embryogenesis and exhibit impaired heart development. This phenotype is reminiscent of that reported for FADD-/- and caspase-8-/- embryos. However, unlike FADD-/- and caspase-8-/- cells, casper-/- embryonic fibroblasts are highly sensitive to FasL- or TNF-induced apoptosis and show rapid induction of caspase activities. NF-kappaB and JNK/SAPK activation is intact in TNF-stimulated casper-/- cells. These results suggest that Casper has two distinct roles: to cooperate with FADD and caspase-8 during embryonic development and to mediate cytoprotection against death factor-induced apoptosis.

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Year:  2000        PMID： 10894163     DOI： 10.1016/s1074-7613(00)80214-9

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  170 in total

Review 1.  FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis.

Authors:  A Krueger; S Baumann; P H Krammer; S Kirchhoff
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

2.  ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2.

Authors:  Rosa Martín-Pérez; Maho Niwa; Abelardo López-Rivas
Journal:  Apoptosis       Date:  2012-04       Impact factor: 4.677

3.  c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis.

Authors:  David W Chang; Zheng Xing; Yi Pan; Alicia Algeciras-Schimnich; Bryan C Barnhart; Shoshanit Yaish-Ohad; Marcus E Peter; Xiaolu Yang
Journal:  EMBO J       Date:  2002-07-15       Impact factor: 11.598

Review 4.  The protein structures that shape caspase activity, specificity, activation and inhibition.

Authors:  Pablo Fuentes-Prior; Guy S Salvesen
Journal:  Biochem J       Date:  2004-12-01       Impact factor: 3.857

Review 5.  The many roles of FAS receptor signaling in the immune system.

Authors:  Andreas Strasser; Philipp J Jost; Shigekazu Nagata
Journal:  Immunity       Date:  2009-02-20       Impact factor: 31.745

6.  Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5.

Authors:  Tai-Guang Jin; Alexei Kurakin; Nordine Benhaga; Karon Abe; Mehrdad Mohseni; Ferry Sandra; Keli Song; Brian K Kay; Roya Khosravi-Far
Journal:  J Biol Chem       Date:  2004-10-14       Impact factor: 5.157

7.  RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.

Authors:  Christopher P Dillon; Ricardo Weinlich; Diego A Rodriguez; James G Cripps; Giovanni Quarato; Prajwal Gurung; Katherine C Verbist; Taylor L Brewer; Fabien Llambi; Yi-Nan Gong; Laura J Janke; Michelle A Kelliher; Thirumala-Devi Kanneganti; Douglas R Green
Journal:  Cell       Date:  2014-05-08       Impact factor: 41.582

Review 8.  Signals from dying cells: tolerance induction by the dendritic cell.

Authors:  Thomas A Ferguson; Hirotaka Kazama
Journal:  Immunol Res       Date:  2005       Impact factor: 2.829

9.  Protective roles for caspase-8 and cFLIP in adult homeostasis.

Authors:  Ricardo Weinlich; Andrew Oberst; Christopher P Dillon; Laura J Janke; Sandra Milasta; John R Lukens; Diego A Rodriguez; Prajwal Gurung; Chandra Savage; Thirumala D Kanneganti; Douglas R Green
Journal:  Cell Rep       Date:  2013-10-03       Impact factor: 9.423

10.  The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

Authors:  Silvia Alvarez-Diaz; Christopher P Dillon; Najoua Lalaoui; Maria C Tanzer; Diego A Rodriguez; Ann Lin; Marion Lebois; Razq Hakem; Emma C Josefsson; Lorraine A O'Reilly; John Silke; Warren S Alexander; Douglas R Green; Andreas Strasser
Journal:  Immunity       Date:  2016-08-11       Impact factor: 31.745
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