| Literature DB >> 10894088 |
Y Okubo1, T Suhara, K Suzuki, K Kobayashi, O Inoue, O Terasaki, Y Someya, T Sassa, Y Sudo, E Matsushima, M Iyo, Y Tateno, M Toru.
Abstract
Using positron emission tomography (PET) and [11C]N-methylspiperone (NMSP), we examined 5-HT2 receptors in the cortex of schizophrenic patients in whom we previously observed decreased prefrontal D1 receptor binding. The subjects were 10 neuroleptic-naive schizophrenic patients, 7 schizophrenic patients who were drug-free but had previously been treated with neuroleptics, and 12 normal controls. A non-significant trend towards decreased prefrontal [11C]NMSP binding was observed in the neuroleptic-treated patients, suggesting a possible effect of previous neuroleptic treatment on the alteration in cortical 5-HT2 function. However, the neuroleptic-naive patients showed no noticeable difference in cortical [11C]NMSP binding compared to controls. Our results do not rule out the role of 5-HT2 function as a crucial site of therapeutic activity of schizophrenia, but they do suggest that cortical 5-HT2 receptors might not be primarily involved in the pathophysiology of schizophrenia.Entities:
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Year: 2000 PMID： 10894088 DOI： 10.1016/s0024-3205(00)80005-3
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037