Literature DB >> 10893002

Enhanced pulmonary pathology in cotton rats upon challenge after immunization with inactivated parainfluenza virus 3 vaccines.

M G Ottolini1, D D Porter, V G Hemming, G A Prince.   

Abstract

Vaccine-induced potentiation was studied in cotton rats immunized with formalin-inactivated human parainfluenza type 3, ultraviolet light-inactivated virus, or infection with live virus. Immunized animals and unimmunized controls were later challenged by intranasal inoculation of live virus and evaluated for pulmonary pathology 4 days later. Animals immunized with either of the inactivated vaccines developed marked peribronchiolitis, perivasculitis, and an alveolar cellular infiltration much more severe than seen in animals infected previously, or in unmanipulated but challenged animals. Disease enhancement after immunization with killed virus is thus a characteristic of a member of each of three genera of the family, Paramyxoviridae, and is not restricted to immunization with formalin-inactivated virus.

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Year:  2000        PMID： 10893002     DOI： 10.1089/vim.2000.13.231

Source DB:  PubMed          Journal:  Viral Immunol        ISSN： 0882-8245            Impact factor:   2.257


  16 in total

1.  Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate.

Authors:  Bo Liang; Sonja Surman; Emerito Amaro-Carambot; Barbora Kabatova; Natalie Mackow; Matthias Lingemann; Lijuan Yang; Jason S McLellan; Barney S Graham; Peter D Kwong; Anne Schaap-Nutt; Peter L Collins; Shirin Munir
Journal:  J Virol       Date:  2015-07-08       Impact factor: 5.103

2.  Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector.

Authors:  Bo Liang; Joan O Ngwuta; Richard Herbert; Joanna Swerczek; David W Dorward; Emerito Amaro-Carambot; Natalie Mackow; Barbora Kabatova; Matthias Lingemann; Sonja Surman; Lijuan Yang; Man Chen; Syed M Moin; Azad Kumar; Jason S McLellan; Peter D Kwong; Barney S Graham; Anne Schaap-Nutt; Peter L Collins; Shirin Munir
Journal:  J Virol       Date:  2016-10-14       Impact factor: 5.103

3.  Zinc binding activity of human metapneumovirus M2-1 protein is indispensable for viral replication and pathogenesis in vivo.

Authors:  Hui Cai; Yu Zhang; Yuanmei Ma; Jing Sun; Xueya Liang; Jianrong Li
Journal:  J Virol       Date:  2015-04-08       Impact factor: 5.103

4.  Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F.

Authors:  Xiang Liu; Bo Liang; Joan Ngwuta; Xueqiao Liu; Sonja Surman; Matthias Lingemann; Peter D Kwong; Barney S Graham; Peter L Collins; Shirin Munir
Journal:  J Virol       Date:  2017-10-27       Impact factor: 5.103

5.  Immunization of macaques with formalin-inactivated respiratory syncytial virus (RSV) induces interleukin-13-associated hypersensitivity to subsequent RSV infection.

Authors:  Rik L De Swart; Thijs Kuiken; Helga H Timmerman; Geert van Amerongen; Bernadette G Van Den Hoogen; Helma W Vos; Herman J Neijens; Arno C Andeweg; Albert D M E Osterhaus
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

6.  Live bivalent vaccine for parainfluenza and influenza virus infections.

Authors:  Yasuko Maeda; Masato Hatta; Ayato Takada; Tokiko Watanabe; Hideo Goto; Gabriele Neumann; Yoshihiro Kawaoka
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

7.  Attenuated Human Parainfluenza Virus Type 1 (HPIV1) Expressing the Fusion Glycoprotein of Human Respiratory Syncytial Virus (RSV) as a Bivalent HPIV1/RSV Vaccine.

Authors:  Natalie Mackow; Emérito Amaro-Carambot; Bo Liang; Sonja Surman; Matthias Lingemann; Lijuan Yang; Peter L Collins; Shirin Munir
Journal:  J Virol       Date:  2015-07-29       Impact factor: 5.103

8.  Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase.

Authors:  Yu Zhang; Yongwei Wei; Xiaodong Zhang; Hui Cai; Stefan Niewiesk; Jianrong Li
Journal:  J Virol       Date:  2014-07-23       Impact factor: 5.103

9.  Chimeric bovine/human parainfluenza virus type 3 expressing respiratory syncytial virus (RSV) F glycoprotein: effect of insert position on expression, replication, immunogenicity, stability, and protection against RSV infection.

Authors:  Bo Liang; Shirin Munir; Emerito Amaro-Carambot; Sonja Surman; Natalie Mackow; Lijuan Yang; Ursula J Buchholz; Peter L Collins; Anne Schaap-Nutt
Journal:  J Virol       Date:  2014-01-29       Impact factor: 5.103

Review 10.  Respiratory viruses and eosinophils: exploring the connections.

Authors:  Helene F Rosenberg; Kimberly D Dyer; Joseph B Domachowske
Journal:  Antiviral Res       Date:  2009-04-16       Impact factor: 5.970
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