OBJECTIVE: Childhood- and adolescence-onset schizophrenic patients with obsessive-compulsive symptoms (OCS) constitute a specific subgroup of schizophrenia. We performed magnetic resonance imaging in this group seeking evidence of neurodevelopmental insults. METHOD: Thirty-two schizophrenic patients were compared with 19 controls. Schizophrenic subjects were divided into 15 patients with OCS (SOCS+ group; onset at 15.5 +/- 1.6 years) and 17 without OCS (SOCS- group; onset at 15.3 +/- 1.3 years). Areas of the hippocampus, frontal lobe, corpus callosum and putamen were analysed morphometrically. RESULTS: The left hippocampus was significantly smaller in the SOCS+ group than in the SOCS- and control groups. CONCLUSION: Reduced size of the left hippocampus in the SOCS+ group supports a neurodevelopmental etiology in this subgroup.
OBJECTIVE: Childhood- and adolescence-onset schizophrenicpatients with obsessive-compulsive symptoms (OCS) constitute a specific subgroup of schizophrenia. We performed magnetic resonance imaging in this group seeking evidence of neurodevelopmental insults. METHOD: Thirty-two schizophrenicpatients were compared with 19 controls. Schizophrenic subjects were divided into 15 patients with OCS (SOCS+ group; onset at 15.5 +/- 1.6 years) and 17 without OCS (SOCS- group; onset at 15.3 +/- 1.3 years). Areas of the hippocampus, frontal lobe, corpus callosum and putamen were analysed morphometrically. RESULTS: The left hippocampus was significantly smaller in the SOCS+ group than in the SOCS- and control groups. CONCLUSION: Reduced size of the left hippocampus in the SOCS+ group supports a neurodevelopmental etiology in this subgroup.
Authors: Yong-Ming Wang; Lai-Quan Zou; Wen-Lan Xie; Zhuo-Ya Yang; Xiong-Zhao Zhu; Eric F C Cheung; Thomas Alrik Sørensen; Arne Møller; Raymond C K Chan Journal: Schizophr Bull Date: 2019-01-01 Impact factor: 9.306
Authors: Kristina T Ciesielski; Matti S Hämäläinen; Daniel A Geller; Sabine Wilhelm; Timothy E Goldsmith; Seppo P Ahlfors Journal: Hum Brain Mapp Date: 2007-12 Impact factor: 5.038
Authors: Thomas Wobrock; Oliver Gruber; Andrew M McIntosh; Susanne Kraft; Anne Klinghardt; Harald Scherk; Wolfgang Reith; Thomas Schneider-Axmann; Stephen M Lawrie; Peter Falkai; Thomas William Moorhead Journal: Eur Arch Psychiatry Clin Neurosci Date: 2010-01-29 Impact factor: 5.270