| Literature DB >> 10891245 |
F Y Miyake1, K Yakushijin, D A Horne.
Abstract
[reaction: see text] A concise synthesis of topsentin A (R(1) = R(2) = H) and nortopsentins B (R(1) = Br, R(2) = H) and D (R(1) = R(2) = H) is described from oxotryptamine 5 via reduction of acyl cyanide 4. Regiospecific bromination of 3-cyanoindole afforded 6-bromo-3-cyanoindole (10) as the major product.Entities:
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Year: 2000 PMID： 10891245 DOI： 10.1021/ol000124g
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005