| Literature DB >> 10891177 |
G B Jones1, J M Wright, G Hynd, J K Wyatt, M Yancisin, M A Brown.
Abstract
[structure: see text] A screening method based on Bergman cycloaromatization products was applied to a compact library of estrogenic-enediyne hybrids. An enediyne candidate identified from the screen was subsequently synthesized, and it induced temperature- and concentration-dependent degradation of human estrogen receptor alpha upon cycloaromatization.Entities:
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Year: 2000 PMID： 10891177 DOI： 10.1021/ol005926q
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005