| Literature DB >> 10891175 |
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Abstract
Treatment of terminal alkynes bearing a remote leaving group with MNR(2) (M = Li, Na, K) gives bicyclo[n.3.0]-1-alkenes (n = 3, 4). The tandem cyclization proceeds through a mechanism involving exo-cyclization of an alkynylmetal intermediate and intramolecular C-H insertion of the resulting carbenoid.Entities:
Year: 2000 PMID： 10891175 DOI： 10.1021/ol0059145
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005