Literature DB >> 10890953

New innovations in scar management.

A D Widgerow, L A Chait, R Stals, P J Stals.   

Abstract

As current aesthetic surgical techniques become more standardized and results more predictable, a fine scar may be the demarcating line between acceptable and unacceptable aesthetic results. With this in mind, a scar management program has been adopted based on the modalities of wound support, hydration, and hastened maturity, all factors gleaned from scientific evidence published over the past 25 years. Tension on a scar in one axis will result in a stretched scar, probably initiated by neutrophils and their neutral proteases [18,26]. Tension on a scar from many directions or intermittently will result in a hypertrophic scar, possibly initiated by lymphocytes but definitely related to a prolongation of the inflammatory process, with increased fibroblast activity and overabundant extracellular matrix secretion [24,26]. The common initiating factor is the tension on the scar, and the critical element needed to counteract this tension is scar support. Clinical experience has shown us that the most reliable way to support a scar is by using microporous tape. Hydration is a second beneficial influence on scar control and is the basis of the use of silicone sheeting and gel [7,29,36]. Alpha Centella cream has two main components. The first is an extract from the plant Bulbine frutescens. This increases hydration under the tape by leaving a layer of fatty vesicles of glycoprotein on the skin surface. This also has antibacterial properties. The second component is the principal terpenoids extracted from the Centella asiatica plant. These include asiatic acid, madecassic acid, and asiaticoside. Centella asiatica has been documented to aid wound healing in a large number of scientific reports [5,12,21,22,33,34,40]. The most beneficial effect appears to be the stimulation of maturation of the scar by the production of type I collagen [4,19] and the resulting decrease in the inflammatory reaction and myofibroblast production. Thus these components have been incorporated into the formulation of a scar management program. This publication reviews much of the available literature relating to scar management and describes the formulation and use of a scar management program based on this information.

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Year:  2000        PMID: 10890953     DOI: 10.1007/s002660010038

Source DB:  PubMed          Journal:  Aesthetic Plast Surg        ISSN: 0364-216X            Impact factor:   2.326


  18 in total

Review 1.  Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise.

Authors:  Mohamed Fizur Nagoor Meeran; Sameer N Goyal; Kapil Suchal; Charu Sharma; Chandragouda R Patil; Shreesh K Ojha
Journal:  Front Pharmacol       Date:  2018-09-04       Impact factor: 5.810

2.  Induction of root colonization by Piriformospora indica leads to enhanced asiaticoside production in Centella asiatica.

Authors:  Jisha Satheesan; Anith K Narayanan; Manjula Sakunthala
Journal:  Mycorrhiza       Date:  2011-06-18       Impact factor: 3.387

3.  Reverse tissue expansion by liposuction deflation for revision of post-surgical thigh scars.

Authors:  Amir E Ibrahim; Saad A Dibo; Shady N Hayek; Bishara S Atiyeh
Journal:  Int Wound J       Date:  2011-09-05       Impact factor: 3.315

4.  Field evaluation of in vitro-induced tetraploid and diploid Centella asiatica (L.) Urban.

Authors:  Wachiraporn Thong-On; Panida Arimatsu; Supaporn Pitiporn; Noppamas Soonthornchareonnon; Sompop Prathanturarug
Journal:  J Nat Med       Date:  2013-03-26       Impact factor: 2.343

5.  Artificial neural network-based model for the prediction of optimal growth and culture conditions for maximum biomass accumulation in multiple shoot cultures of Centella asiatica.

Authors:  Archana Prasad; Om Prakash; Shakti Mehrotra; Feroz Khan; Ajay Kumar Mathur; Archana Mathur
Journal:  Protoplasma       Date:  2016-04-11       Impact factor: 3.356

6.  Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all.

Authors:  Kashmira J Gohil; Jagruti A Patel; Anuradha K Gajjar
Journal:  Indian J Pharm Sci       Date:  2010-09       Impact factor: 0.975

7.  Asiatic acid isolated from Centella asiatica inhibits TGF-β1-induced collagen expression in human keloid fibroblasts via PPAR-γ activation.

Authors:  Difei Bian; Jizhou Zhang; Xin Wu; Yannong Dou; Yan Yang; Qian Tan; Yufeng Xia; Zhunan Gong; Yue Dai
Journal:  Int J Biol Sci       Date:  2013-10-25       Impact factor: 6.580

Review 8.  Use of tape for the management of hypertrophic scar development: A comprehensive review.

Authors:  Sarah O'Reilly; Erin Crofton; Jason Brown; Jennifer Strong; Jenny Ziviani
Journal:  Scars Burn Heal       Date:  2021-07-12

9.  Porcine cholecyst-derived scaffold promotes full-thickness wound healing in rabbit.

Authors:  Deepa Revi; Vadavanath Prabhakaran Vineetha; Jaseer Muhamed; Akhila Rajan; Thapasimuthu Vijayamma Anilkumar
Journal:  J Tissue Eng       Date:  2013-12-18       Impact factor: 7.813

Review 10.  Centella asiatica in cosmetology.

Authors:  Wiesława Bylka; Paulina Znajdek-Awiżeń; Elżbieta Studzińska-Sroka; Małgorzata Brzezińska
Journal:  Postepy Dermatol Alergol       Date:  2013-02-20       Impact factor: 1.837

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