Literature DB >> 10890890

A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13.

A J Muller1, A K Teresky, A J Levine.   

Abstract

Inbred 129 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes. The inherent genetic defects that underlie male GCT susceptibility in the 129 mouse strain are unknown. GCT incidence is increased in 129 strain males that lack functional p53 protein, and we have used this finding to facilitate the generation of panels of GCT-bearing intercross and backcross mice for genetic mapping analysis. A 129 strain locus, designated pgct1, that segregates with the male GCT phenotype has been identified on chromosome 13 near D13Mit188. This region of murine chromosome 13 may be syntenic to a portion of human chromosome 5q that is implicated in male GCT susceptibility in humans.

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Year:  2000        PMID： 10890890      PMCID： PMC26963          DOI： 10.1073/pnas.140208197

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  40 in total

1.  Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain.

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Journal:  Nat Genet       Date:  1999-10       Impact factor: 38.330

Review 2.  A Macintosh program for storage and analysis of experimental genetic mapping data.

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Journal:  J Natl Cancer Inst       Date:  1966-12       Impact factor: 13.506

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Journal:  APMIS       Date:  1998-01       Impact factor: 3.205

5.  Mutations of the p53 gene do not occur in testis cancer.

Authors:  H Q Peng; D Hogg; D Malkin; D Bailey; B L Gallie; M Bulbul; M Jewett; J Buchanan; P E Goss
Journal:  Cancer Res       Date:  1993-08-01       Impact factor: 12.701

6.  The p53 and mdm-2 genes in human testicular germ-cell tumors.

Authors:  G Riou; M Barrois; S Prost; M J Terrier; C Theodore; A J Levine
Journal:  Mol Carcinog       Date:  1995-03       Impact factor: 4.784

7.  Tumor spectrum analysis in p53-mutant mice.

Authors:  T Jacks; L Remington; B O Williams; E M Schmitt; S Halachmi; R T Bronson; R A Weinberg
Journal:  Curr Biol       Date:  1994-01-01       Impact factor: 10.834

8.  Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos.

Authors:  P P Tam; M H Snow
Journal:  J Embryol Exp Morphol       Date:  1981-08

9.  Increased p53 protein does not correlate to p53 gene mutations in microdissected human testicular germ cell tumors.

Authors:  N S Schenkman; I A Sesterhenn; L Washington; Y A Tong; C M Weghorst; G S Buzard; S Srivastava; J W Moul
Journal:  J Urol       Date:  1995-08       Impact factor: 7.450

10.  Invasive behaviour of mouse primordial germ cells in vitro.

Authors:  D Stott; C C Wylie
Journal:  J Cell Sci       Date:  1986-12       Impact factor: 5.285
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  8 in total

Review 1.  The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation.

Authors:  Arnold J Levine; Anna M Puzio-Kuter; Chang S Chan; Pierre Hainaut
Journal:  Cold Spring Harb Perspect Med       Date:  2016-09-01       Impact factor: 6.915

2.  Stem cell biology meets p53.

Authors:  Anna M Puzio-Kuter; Arnold J Levine
Journal:  Nat Biotechnol       Date:  2009-10       Impact factor: 54.908

3.  One billion years of p53/p63/p73 evolution.

Authors:  Vladimir A Belyi; Arnold J Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-13       Impact factor: 11.205

Review 4.  Reprogramming of germ cells into pluripotency.

Authors:  Yoichi Sekita; Toshinobu Nakamura; Tohru Kimura
Journal:  World J Stem Cells       Date:  2016-08-26       Impact factor: 5.326

5.  Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.

Authors:  G Steele-Perkins; W Fang; X H Yang; M Van Gele; T Carling; J Gu; I M Buyse; J A Fletcher; J Liu; R Bronson; R B Chadwick; A de la Chapelle; X Zhang; F Speleman; S Huang
Journal:  Genes Dev       Date:  2001-09-01       Impact factor: 11.361

Review 6.  p53 Research: the past thirty years and the next thirty years.

Authors:  David Lane; Arnold Levine
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-05-12       Impact factor: 10.005

7.  Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation.

Authors:  Philip D Anderson; Vicki R Nelson; Paul J Tesar; Joseph H Nadeau
Journal:  Cancer Res       Date:  2009-11-24       Impact factor: 12.701

8.  Reprogramming primordial germ cells into pluripotent stem cells.

Authors:  Gabriela Durcova-Hills; Fuchou Tang; Gina Doody; Reuben Tooze; M Azim Surani
Journal:  PLoS One       Date:  2008-10-27       Impact factor: 3.240
  8 in total

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