C Ayala1, K E Blackwell. 1. Department of Surgery, University of California Los Angeles School of Medicine 90095, USA.
Abstract
OBJECTIVE: To determine the incidence of perioperative protein C deficiency in patients undergoing free flap reconstruction of cancer-related defects in the head and neck. STUDY DESIGN: Prospective case series. INTERVENTION: Ten patients underwent microvascular reconstruction after surgical therapy of carcinomas of the oral cavity or oropharynx. Coagulation studies were determined in all patients 72 hours after surgery. SETTING: Academic tertiary care medical center RESULTS: Protein C deficiency was detected in 70% of patients. One free flap failure was attributed to protein C deficiency. CONCLUSIONS: Vitamin K-dependent clotting factors are frequently deficient during the postoperative period after major head and neck surgery, which may result in a state of hypercoagulability. Protein C deficiency should be considered as a possible cause of free flap thrombosis in patients who undergo microvascular head and neck reconstruction.
OBJECTIVE: To determine the incidence of perioperative protein C deficiency in patients undergoing free flap reconstruction of cancer-related defects in the head and neck. STUDY DESIGN: Prospective case series. INTERVENTION: Ten patients underwent microvascular reconstruction after surgical therapy of carcinomas of the oral cavity or oropharynx. Coagulation studies were determined in all patients 72 hours after surgery. SETTING: Academic tertiary care medical center RESULTS:Protein C deficiency was detected in 70% of patients. One free flap failure was attributed to protein C deficiency. CONCLUSIONS:Vitamin K-dependent clotting factors are frequently deficient during the postoperative period after major head and neck surgery, which may result in a state of hypercoagulability. Protein C deficiency should be considered as a possible cause of free flap thrombosis in patients who undergo microvascular head and neck reconstruction.
Authors: Andreas M Fichter; Thomas Mücke; Lucas M Ritschl; Marie-Kristin Hofmann; Constantin T Wolff; Leonard H Schmidt; Klaus-Dietrich Wolff Journal: Sci Rep Date: 2021-04-22 Impact factor: 4.379
Authors: Thomas Mücke; Alexander Hapfelmeier; Leonard H Schmidt; Andreas M Fichter; Anastasios Kanatas; Klaus-Dietrich Wolff; Lucas M Ritschl Journal: Sci Rep Date: 2020-01-22 Impact factor: 4.379