| Literature DB >> 10890170 |
G M Cingolani1, A Di Stefano, B Mosciatti, F Napolitani, G Giorgioni, M Ricciutelli, F Claudi.
Abstract
The synthesis and in vitro chemical and enzymatic stability of L-(+)-3-(3-hydroxy-4-pivaloyloxybenzyl)-2,5-diketomorpholine (9) as L-Dopa prodrug are described. Prodrug 9 possesses a good lipophilicity (log P = 2.153 +/- 0.017), is stable in aqueous buffer solutions (pH 1.3 and 7.4), and in 80% rat and human plasma it is turned into L-Dopa.Entities:
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Year: 2000 PMID： 10890170 DOI： 10.1016/s0960-894x(00)00249-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823