| Literature DB >> 10890167 |
S Rodier1, Y Le Huérou, B Renoux, J Doyon, P Renard, A Pierré, J P Gesson, R Grée.
Abstract
A set of 16 new simplified analogues of acetogenins has been designed based on: (i) the replacement of the bis THF moiety of these natural products by an ethylene glycol bis ether unit; (ii) the introduction of different lipophilic side chains (alkyl, aryl, dialkylamino, O-cholesteryl); (iii) the presence of the same terminal isolactone. In vitro cytotoxic activity against L1210 leukemia is reported.Entities:
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Year: 2000 PMID： 10890167 DOI： 10.1016/s0960-894x(00)00236-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823