| Literature DB >> 10890162 |
J Zhang1, S Didierlaurent, M Fortin, D Lefrançois, E Uridat, J P Vevert.
Abstract
Random screening of compounds in endothelin receptor (ET(A) and ET(B)) binding assays led to the discovery of a new class of pyrazol-5-ol ligands. Characterization of structural features crucial for binding activities of these pyrazol-5-ols, by structure activity-relationship (SAR) studies, allowed us to design a novel class of pyrazole-5-carboxylic acids as more potent ET antagonists.Entities:
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Year: 2000 PMID： 10890162 DOI： 10.1016/s0960-894x(00)00232-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823