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Literature DB >> 10890024

Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation.

M Cascante¹, J J Centelles, R L Veech, W N Lee, L G Boros.

Abstract

Metabolic control analysis predicts that stimulators of transketolase enzyme synthesis such as thiamin (vitamin B-1) support a high rate of nucleic acid ribose synthesis necessary for tumor cell survival, chemotherapy resistance, and proliferation. Metabolic control analysis also predicts that transketolase inhibitor drugs will have the opposite effect on tumor cells. This may have important implications in the nutrition and future treatment of patients with cancer.

Entities: Chemical Disease Gene Species

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Year: 2000 PMID： 10890024 DOI： 10.1207/S15327914NC3602_2

Source DB: PubMed Journal: Nutr Cancer ISSN： 0163-5581 Impact factor: 2.900

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Cited

15 in total

1. Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.

Authors: Isaac Marin-Valencia; Steve K Cho; Dinesh Rakheja; Kimmo J Hatanpaa; Payal Kapur; Tomoyuki Mashimo; Ashish Jindal; Vamsidhara Vemireddy; Levi B Good; Jack Raisanen; Xiankai Sun; Bruce Mickey; Changho Choi; Masaya Takahashi; Osamu Togao; Juan M Pascual; Ralph J Deberardinis; Elizabeth A Maher; Craig R Malloy; Robert M Bachoo
Journal: NMR Biomed Date: 2012-03-01 Impact factor: 4.044

Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation.

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