Literature DB >> 10889536

Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families.

M Auranen1, T Nieminen, S Majuri, R Vanhala, L Peltonen, I Järvelä.   

Abstract

The role of genetic factors in the etiology of the autistic spectrum of disorders has clearly been demonstrated. Ten chromosomal regions, on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q have potentially been linked to autism.1-8 We have analyzed these chromosomal regions in a total of 17 multiplex families with autism originating from the isolated Finnish population by pairwise linkage analysis and sib-pair analysis. Mild evidence for putative contribution was found only with the 1p chromosomal region in the susceptibility to autism. Our data suggest that additional gene loci exist for autism which will be detectable in and even restricted to the isolated Finnish population.

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Year:  2000        PMID： 10889536     DOI： 10.1038/sj.mp.4000708

Source DB:  PubMed          Journal:  Mol Psychiatry        ISSN： 1359-4184            Impact factor:   15.992


  18 in total

1.  Excess of twins among affected sibling pairs with autism: implications for the etiology of autism.

Authors:  D A Greenberg; S E Hodge; J Sowinski; D Nicoll
Journal:  Am J Hum Genet       Date:  2001-10-02       Impact factor: 11.025

2.  Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity.

Authors:  J D Buxbaum; J M Silverman; C J Smith; M Kilifarski; J Reichert; E Hollander; B A Lawlor; M Fitzgerald; D A Greenberg; K L Davis
Journal:  Am J Hum Genet       Date:  2001-05-14       Impact factor: 11.025

3.  AMPD1 functional variants associated with autism in Han Chinese population.

Authors:  Lusi Zhang; Jianjun Ou; Xiaojuan Xu; Yu Peng; Hui Guo; Yongcheng Pan; Jingjing Chen; Tianyun Wang; Hao Peng; Qiong Liu; Di Tian; Qian Pan; Xiaobin Zou; Jingping Zhao; Zhengmao Hu; Kun Xia
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2014-08-26       Impact factor: 5.270

4.  Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism.

Authors:  Valerie W Hu; Tewarit Sarachana; Kyung Soon Kim; AnhThu Nguyen; Shreya Kulkarni; Mara E Steinberg; Truong Luu; Yinglei Lai; Norman H Lee
Journal:  Autism Res       Date:  2009-04       Impact factor: 5.216

Review 5.  Early pharmacological treatment of autism: a rationale for developmental treatment.

Authors:  Terrence C Bethea; Linmarie Sikich
Journal:  Biol Psychiatry       Date:  2007-02-15       Impact factor: 13.382

6.  Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors.

Authors:  James S Sutcliffe; Ryan J Delahanty; Harish C Prasad; Jacob L McCauley; Qiao Han; Lan Jiang; Chun Li; Susan E Folstein; Randy D Blakely
Journal:  Am J Hum Genet       Date:  2005-07-01       Impact factor: 11.025

7.  Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.

Authors:  D Q Ma; P L Whitehead; M M Menold; E R Martin; A E Ashley-Koch; H Mei; M D Ritchie; G R Delong; R K Abramson; H H Wright; M L Cuccaro; J P Hussman; J R Gilbert; M A Pericak-Vance
Journal:  Am J Hum Genet       Date:  2005-07-15       Impact factor: 11.025

Review 8.  Genetic advances in autism hinge on the method of measuring symptoms.

Authors:  Richard D Todd
Journal:  Curr Psychiatry Rep       Date:  2005-04       Impact factor: 5.285

9.  On the twin risk in autism.

Authors:  Joachim Hallmayer; Emma J Glasson; Carol Bower; Beverly Petterson; Lisa Croen; Judith Grether; Neil Risch
Journal:  Am J Hum Genet       Date:  2002-09-12       Impact factor: 11.025

10.  Sequencing and analyzing the t(1;7) reciprocal translocation breakpoints associated with a case of childhood-onset schizophrenia/autistic disorder.

Authors:  Jacquelyn R Idol; Anjene M Addington; Robert T Long; Judith L Rapoport; Eric D Green
Journal:  J Autism Dev Disord       Date:  2007-09-19
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