Literature DB >> 10889461

NMDA receptor activation: critical role in oxidant tissue injury.

S I Said1, H Pakbaz, H I Berisha, S Raza.   

Abstract

The excitatory amino acid glutamate serves important neurologic functions, but overactivation of its N-methyl-D-aspartate (NMDA) receptor is toxic to neurons (excitotoxicity). We report that NMDA receptor blocker MK-801 (dizocilpine maleate) attenuated oxidant injury induced by paraquat or by xanthine oxidase. We conclude that excitotoxicity may be a key factor in oxidant tissue injury.

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Year:  2000        PMID： 10889461     DOI： 10.1016/s0891-5849(00)00289-6

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  9 in total

1.  Mesenteric artery clamping/unclamping-induced acute lung injury is attenuated by N-methyl-D-aspartate antagonist dextromethorphan.

Authors:  R Ben-Abraham; M Guttman; R Flaishon; N Marouani; D Niv; Avi A Weinbroum
Journal:  Lung       Date:  2006-11-10       Impact factor: 2.584

2.  Mechanism of cytotoxicity of paraquat.

Authors:  Tetsuhito Fukushima; Keiko Tanaka; Heejin Lim; Masaki Moriyama
Journal:  Environ Health Prev Med       Date:  2002-07       Impact factor: 3.674

3.  N-methyl-D-aspartate receptor blockers attenuate bleomycin-induced pulmonary fibrosis by inhibiting endogenous mesenchymal stem cells senescence.

Authors:  Pu Huang; Yan Zhou; Xiao-Hong Li; Yun-Na Zhang; Hai-Peng Cheng; Jia-Feng Fu; Wei Liu; Shaojie Yue; Zi-Qiang Luo
Journal:  Ann Transl Med       Date:  2022-06

Review 4.  Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity.

Authors:  Peter Kovacic; Ratnasamy Somanathan
Journal:  Oxid Med Cell Longev       Date:  2010 Jan-Feb       Impact factor: 6.543

5.  Epithelium-dependent effect of L-glutamate on airways: involvement of prostaglandins.

Authors:  Apostolia A Hatziefthimiou; Konstantinos I Gourgoulianis; Paschalis-Adam Molyvdas
Journal:  Mediators Inflamm       Date:  2002-02       Impact factor: 4.711

6.  NMDA Receptor Antagonist Attenuates Bleomycin-Induced Acute Lung Injury.

Authors:  Yang Li; Yong Liu; XiangPing Peng; Wei Liu; FeiYan Zhao; DanDan Feng; JianZhong Han; YanHong Huang; SiWei Luo; Lian Li; Shao Jie Yue; QingMei Cheng; XiaoTing Huang; ZiQiang Luo
Journal:  PLoS One       Date:  2015-05-05       Impact factor: 3.240

7.  The role of tumour suppressor PDCD4 in beta cell death in hypoxia.

Authors:  Sandeep Kumar; Claire E Marriott; Nouf F Alhasawi; Adrian J Bone; Wendy M Macfarlane
Journal:  PLoS One       Date:  2017-07-27       Impact factor: 3.240

8.  N-methyl-D-aspartate receptor activation mediates lung fibroblast proliferation and differentiation in hyperoxia-induced chronic lung disease in newborn rats.

Authors:  YanRui Wang; ShaoJie Yue; ZiQiang Luo; ChuanDing Cao; XiaoHe Yu; ZhengChang Liao; MingJie Wang
Journal:  Respir Res       Date:  2016-10-21

9.  NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis.

Authors:  Xiaohong Li; Chen Li; Yiting Tang; Yanhong Huang; Qingmei Cheng; Xiaoting Huang; Feiyan Zhao; Caixia Hao; Dandan Feng; Jianping Xu; Jianzhong Han; Siyuan Tang; Wei Liu; Shaojie Yue; Ziqiang Luo
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2018-05-03       Impact factor: 5.464
  9 in total

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