| Literature DB >> 10888868 |
L L Molday1, A R Rabin, R S Molday.
Abstract
Mutations in the gene encoding ABCR are responsible for Stargardt macular dystrophy. Here we show by immunofluorescence microscopy and western-blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. Our results suggest that the loss in central vision experienced by Stargardt patients arises directly from ABCR-mediated foveal cone degeneration.Entities:
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Year: 2000 PMID： 10888868 DOI： 10.1038/77004
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330