Literature DB >> 10888866

Hepatocyte migration during liver development requires Prox1.

B Sosa-Pineda1, J T Wigle, G Oliver.   

Abstract

Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.

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Year:  2000        PMID： 10888866     DOI： 10.1038/76996

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  108 in total

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