Literature DB >> 10888336

Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors.

L Chan1, T Stefanac, N Turcotte, Z Hu, Y Chen, J Bédard, S May, H Jin.   

Abstract

Following the identification of first pass metabolism issues with our recently described anti-HCMV compounds, the naphthyridines and isoquinolines, we have designed a class of novel metabolically stable and orally bioavailable anti-HCMV agents, the dihydroisoquinolines.

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Year:  2000        PMID: 10888336     DOI: 10.1016/s0960-894x(00)00265-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Nitrophenyl-Group-Containing Heterocycles. I. Synthesis, Characterization, Crystal Structure, Anticancer Activity, and Antioxidant Properties of Some New 5,6,7,8-Tetrahydroisoquinolines Bearing 3(4)-Nitrophenyl Group.

Authors:  Eman M Sayed; Reda Hassanien; Nasser Farhan; Hanan F Aly; Khaled Mahmoud; Shaaban K Mohamed; Joel T Mague; Etify A Bakhite
Journal:  ACS Omega       Date:  2022-03-04
  1 in total

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