Literature DB >> 10888330

Novel nikkomycin analogues: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase.

K Obi1, J Uda, K Iwase, O Sugimoto, H Ebisu, A Matsuda.   

Abstract

A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity.

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Year:  2000        PMID： 10888330     DOI： 10.1016/s0960-894x(00)00256-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

2.  Phosphonoxins III: synthesis of α-aminophosphonate analogs of antifungal polyoxins with anti-Giardia activity.

Authors:  Michael Staake; Jay Chauhan; Ding Zhou; Aaron Shanker; Atasi De Chatterjee; Siddhartha Das; Steven E Patterson
Journal:  Org Lett       Date:  2010-10-15       Impact factor: 6.005

3.  Pharmacokinetics of nikkomycin Z after single rising oral doses.

Authors:  David E Nix; Robert R Swezey; Richard Hector; John N Galgiani
Journal:  Antimicrob Agents Chemother       Date:  2009-04-06       Impact factor: 5.191
  3 in total

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