Literature DB >> 10887493

ErbB2 activation and signal transduction in normal and malignant mammary cells.

N E Hynes1.   

Abstract

One of the first consistent genetic alterations found in human breast tumors was amplification of the erbB-2 gene leading to overexpression of the protein. ErbB2 is a member of the ErbB/type I family of receptor tyrosine kinases which also includes epidermal growth factor receptor, ErbB3 and ErbB4. The role of ErbB2 in the biology of the mammary gland as well as in breast cancer development is under intense investigation. In clinical studies, the ErbB2 protein level has been examined for its utility in predicting patient prognosis and response to treatment. The ErbB2 receptor is also being tested as a target for tumor directed therapies.

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Year:  1996        PMID： 10887493     DOI： 10.1007/BF02013643

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  59 in total

1.  Amplification, overexpression, and rearrangement of the erbB-2 protooncogene in primary human stomach carcinomas.

Authors:  J B Park; J S Rhim; S C Park; S W Kimm; M H Kraus
Journal:  Cancer Res       Date:  1989-12-01       Impact factor: 12.701

2.  Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo.

Authors:  D F Stern; M P Kamps; H Cao
Journal:  Mol Cell Biol       Date:  1988-09       Impact factor: 4.272

3.  The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.

Authors:  D J Riese; T M van Raaij; G D Plowman; G C Andrews; D F Stern
Journal:  Mol Cell Biol       Date:  1995-10       Impact factor: 4.272

4.  p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor.

Authors:  R M Hudziak; G D Lewis; M Winget; B M Fendly; H M Shepard; A Ullrich
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

5.  Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer.

Authors:  N R Lemoine; S Staddon; C Dickson; D M Barnes; W J Gullick
Journal:  Oncogene       Date:  1990-02       Impact factor: 9.867

6.  Medullary carcinoma is associated with expression of intercellular adhesion molecule-1. Implication to its morphology and its clinical behavior.

Authors:  S S Bacus; C R Zelnick; D M Chin; Y Yarden; D B Kaminsky; J Bennington; D Wen; J N Marcus; D L Page
Journal:  Am J Pathol       Date:  1994-12       Impact factor: 4.307

7.  Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2.

Authors:  R R Beerli; D Graus-Porta; K Woods-Cook; X Chen; Y Yarden; N E Hynes
Journal:  Mol Cell Biol       Date:  1995-12       Impact factor: 4.272

8.  Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling.

Authors:  D Graus-Porta; R R Beerli; N E Hynes
Journal:  Mol Cell Biol       Date:  1995-03       Impact factor: 4.272

9.  c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer.

Authors:  H B Muss; A D Thor; D A Berry; T Kute; E T Liu; F Koerner; C T Cirrincione; D R Budman; W C Wood; M Barcos
Journal:  N Engl J Med       Date:  1994-05-05       Impact factor: 91.245

Review 10.  Neu and its ligands: from an oncogene to neural factors.

Authors:  E Peles; Y Yarden
Journal:  Bioessays       Date:  1993-12       Impact factor: 4.345
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  7 in total

Review 1.  A role for fibroblast growth factor signaling in the lobuloalveolar development of the mammary gland.

Authors:  D Jackson; J Bresnick; C Dickson
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-10       Impact factor: 2.673

2.  The PeptideAtlas of the Domestic Laying Hen.

Authors:  James McCord; Zhi Sun; Eric W Deutsch; Robert L Moritz; David C Muddiman
Journal:  J Proteome Res       Date:  2017-02-14       Impact factor: 4.466

Review 3.  Genetic analysis of breast cancer progression.

Authors:  S H Dairkee; H S Smith
Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-04       Impact factor: 2.673

Review 4.  Protein kinase C isozymes and substrates in mammary carcinogenesis.

Authors:  S C Kiley; J Welsh; C J Narvaez; S Jaken
Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-04       Impact factor: 2.673

Review 5.  Growth factor and sex steroid interactions in breast cancer.

Authors:  N J Kenney; R B Dickson
Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-04       Impact factor: 2.673

Review 6.  ErbB4/HER4: role in mammary gland development, differentiation and growth inhibition.

Authors:  Rebecca S Muraoka-Cook; Shu-Mang Feng; Karen E Strunk; H Shelton Earp
Journal:  J Mammary Gland Biol Neoplasia       Date:  2008-04-25       Impact factor: 2.673

7.  High cell-surface density of HER2 deforms cell membranes.

Authors:  Inhee Chung; Mike Reichelt; Lily Shao; Robert W Akita; Hartmut Koeppen; Linda Rangell; Gabriele Schaefer; Ira Mellman; Mark X Sliwkowski
Journal:  Nat Commun       Date:  2016-09-07       Impact factor: 14.919
  7 in total

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