Literature DB >> 10887280

Role of cAMP-dependent signal transduction in the control of T lymphocyte activation.

E M Kuklina1, S V Shirshev.   

Abstract

The role of cAMP in the regulation of antigen-dependent differentiation of T cells is discussed with consideration of the molecular mechanisms of cAMP effects. Characteristics of activation signal in various T lymphocyte subpopulations determining differential sensitivity to cAMP are reviewed. Specific attention is given to the involvement of the cAMP-dependent messenger system in the formation of the spectrum of secreted cytokines because their level and ratio determine the type of immune response.

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Year:  2000        PMID： 10887280

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  5 in total

1.  Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms.

Authors:  Sonemany Salinthone; Robynn V Schillace; Catherine Tsang; John W Regan; Dennis N Bourdette; Daniel W Carr
Journal:  J Nutr Biochem       Date:  2010-10-30       Impact factor: 6.048

2.  Lipoic acid stimulates cAMP production in T lymphocytes and NK cells.

Authors:  R V Schillace; N Pisenti; N Pattamanuch; S Galligan; G H Marracci; D N Bourdette; D W Carr
Journal:  Biochem Biophys Res Commun       Date:  2007-01-03       Impact factor: 3.575

3.  Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cells.

Authors:  Sonemany Salinthone; Robynn V Schillace; Gail H Marracci; Dennis N Bourdette; Daniel W Carr
Journal:  J Neuroimmunol       Date:  2008-06-17       Impact factor: 3.478

4.  Effects of Zuogui Pill () and Yougui Pill () on the expression of brain-derived neurotrophic factor and cyclic adenosine monophosphate/protein kinase A signaling transduction pathways of axonal regeneration in model rats with experimental autoimmune encephalomyelitis.

Authors:  Yi-zhou Wang; Shuang Kou; Ling-yun Gu; Qi Zheng; Ming Li; Fang Qi; Hui Zhao; Lei Wang
Journal:  Chin J Integr Med       Date:  2012-12-03       Impact factor: 1.978

Review 5.  Targeting G protein coupled receptor-related pathways as emerging molecular therapies.

Authors:  Abdelaziz Ghanemi
Journal:  Saudi Pharm J       Date:  2013-08-13       Impact factor: 4.330
  5 in total

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