| Literature DB >> 10886724 |
S Inamoto1, S Murao, M Yokoyama, S Kitazawa, S Maeda.
Abstract
S-100 proteins (S100) are characterized by calcium-binding ability with two structural EF hands. Several S100 are expressed in cardiomyocytes and thought to play a crucial role in calcium signaling. To examine whether the expression of S100 is a response to detectable myocardial damage or regeneration, we investigated, immunohistochemically, the expression of S100A4 and S100A11 in the isoproterenol (ISP)-treated rat heart. Definite expression of S100A4 and S100A11 was demonstrated in normal cardiomyocytes, and their staining patterns were enhanced in the ISP-treated rat heart, suggesting the possible involvement of S1-A4 and S100A11 in ISP-induced myocardial damage.Entities:
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Year: 2000 PMID: 10886724 DOI: 10.1046/j.1440-1827.2000.01069.x
Source DB: PubMed Journal: Pathol Int ISSN: 1320-5463 Impact factor: 2.534