| Literature DB >> 10886538 |
F Z Al-Faleh1, A Aljumah, M Rezeig, M Al-Otaibi, M Alahdal, S Al-Humayed, I Mayet, M Al-Juhani, M Al-Karawi, K George, F Sbeih.
Abstract
Between 1996 and 1997, we conducted a multicentre study to assess the effect of combination therapy of interferon (IFN) + ribavirin on chronic hepatitis C genotype 4. Ninety-seven patients were enrolled. Sixty-eight patients (47 male and 21 female) were non-responders to previous therapy with IFN (Group I). Twenty-nine patients (19 male and 10 female) were new (Group II). Following treatment with IFN, 23% in Group I and 9% in Group II had a sustained biochemical response. Only 12% in Group I and 5% in Group II achieved a sustained virological response. Virus load was found to be the major factor determining response, followed by histology grading and staging. Like HCV genotype 1, HCV genotype 4 seems to have a poor response to therapy.Entities:
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Year: 2000 PMID： 10886538 DOI： 10.1046/j.1365-2893.2000.00213.x
Source DB: PubMed Journal: J Viral Hepat ISSN： 1352-0504 Impact factor: 3.728