Literature DB >> 10886253

Peptide T does not ameliorate experimental autoimmune encephalomyelitis (EAE) in Lewis rats.

I Sáez-Torres1, C Espejo, J J Pérez, N Acarín, X Montalban, E M Martínez-Cáceres.   

Abstract

Peptide T has been shown to inhibit T cell activation and cytokine production and function. Moreover, it has been reported to be a safe treatment in humans. We have studied the ability of peptide T to prevent or ameliorate EAE in Lewis rats. Peptide T was administered subcutaneously at different doses and phases of the disease according to several treatment protocols, but we could not observe a consistent effect of peptide T ameliorating the disease. Lymph node cell proliferation and IL-4 and interferon-gamma production were also studied. We conclude that peptide T neither prevents nor ameliorates EAE in Lewis rats.

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Year:  2000        PMID： 10886253      PMCID： PMC1905669          DOI： 10.1046/j.1365-2249.2000.01259.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  35 in total

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Authors:  C B Pert; M R Ruff
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4.  CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis. Relationship to vasoactive intestinal polypeptide.

Authors:  M R Ruff; B M Martin; E I Ginns; W L Farrar; C B Pert
Journal:  FEBS Lett       Date:  1987-01-19       Impact factor: 4.124

5.  Peptide T blocks GP120/CCR5 chemokine receptor-mediated chemotaxis.

Authors:  L S Redwine; C B Pert; J D Rone; R Nixon; M Vance; B Sandler; M D Lumpkin; D J Dieter; M R Ruff
Journal:  Clin Immunol       Date:  1999-11       Impact factor: 3.969

6.  The development and characterization of encephalitogenic cloned T cells specific for myelin proteolipid protein.

Authors:  R C van der Veen; J L Trotter; W F Hickey; J A Kapp
Journal:  J Neuroimmunol       Date:  1990-02       Impact factor: 3.478

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Authors:  S Zamvil; P Nelson; J Trotter; D Mitchell; R Knobler; R Fritz; L Steinman
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8.  AIDS and its dementia as a neuropeptide disorder: role of VIP receptor blockade by human immunodeficiency virus envelope.

Authors:  C B Pert; C C Smith; M R Ruff; J M Hill
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9.  Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions.

Authors:  H Lassmann; C Brunner; M Bradl; C Linington
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10.  An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

Authors:  N H Ruddle; C M Bergman; K M McGrath; E G Lingenheld; M L Grunnet; S J Padula; R B Clark
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