| Literature DB >> 10884055 |
M Kuru1, Y Ueta, R Serino, M Nakazato, Y Yamamoto, I Shibuya, H Yamashita.
Abstract
The effects of i.c.v. administration of orexin/hypocretin on plasma ACTH, corticosterone and c-fos mRNA in the paraventricular nucleus (PVN) of the rat were examined. Plasma ACTH levels were markedly increased at 30 min after i.c.v. administration of orexin-A. Plasma corticosterone levels were significantly increased in a dose-related manner 30 min after i.c.v. administration of orexin-A and orexin-B. In situ hybridization histochemistry revealed that the induction of the c-fos mRNA in the parvocellular division of the PVN was increased in a dose-related manner 30 min after i.c.v. administration of orexin-A and orexin-B. These results suggest that central orexin/hypocretin activates hypothalamo-pituitary-adrenal (HPA) axis and may be involved in stress-induced activation of the HPA axis.Entities:
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Year: 2000 PMID： 10884055 DOI： 10.1097/00001756-200006260-00034
Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837