Literature DB >> 10882795

Effects of MK-801 on D1 dopamine receptor-mediated immediate early gene expression in the dopamine-depleted striatum.

A Ganguly1, K A Keefe.   

Abstract

Previous work indicates that intrastriatal administration of MK-801 does not completely block D1 agonist-induced gene expression in dopamine-depleted rats. The present study examined the effects of systemic MK-801 on such gene expression. A low dose of MK-801 did not affect induction of c-fos or zif268. A high dose completely blocked induction of c-fos, but only slightly suppressed zif268. The data suggest that NMDA receptor activity may not always be necessary for D1-induced gene expression.

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Year:  2000        PMID： 10882795     DOI： 10.1016/s0006-8993(00)02435-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

1.  Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822.

Authors:  David Wirtshafter
Journal:  Pharmacol Biochem Behav       Date:  2007-01-20       Impact factor: 3.533

2.  Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamine.

Authors:  Amy J Ramsey; Aki Laakso; Michel Cyr; Tatyana D Sotnikova; Ali Salahpour; Ivan O Medvedev; Linda A Dykstra; Raul R Gainetdinov; Marc G Caron
Journal:  Neuropsychopharmacology       Date:  2008-01-09       Impact factor: 7.853

3.  Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation.

Authors:  Christopher D Howard; Elissa D Pastuzyn; Melissa L Barker-Haliski; Paul A Garris; Kristen A Keefe
Journal:  J Neurochem       Date:  2013-04-01       Impact factor: 5.372

4.  Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling.

Authors:  Daniella Rylander; Alessandra Recchia; Flora Mela; Andrzej Dekundy; Wojciech Danysz; M Angela Cenci
Journal:  J Pharmacol Exp Ther       Date:  2009-04-08       Impact factor: 4.030
  4 in total

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