Literature DB >> 10882602

Production of interleukin-18 in human tuberculosis.

R Vankayalapati1, B Wizel, S E Weis, B Samten, W M Girard, P F Barnes.   

Abstract

To investigate the role of interleukin (IL)-18 in human tuberculosis, IL-18 production was evaluated in blood and at the site of disease in patients with tuberculosis. Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells (PBMC) from tuberculosis patients secreted less IL-18 and interferon-gamma (IFN-gamma) than did PBMC from healthy persons reactive to tuberculin. M. tuberculosis-induced IFN-gamma production was inhibited by anti-IL-18 and enhanced by recombinant IL-18. Alveolar macrophages secreted IL-18 in response to M. tuberculosis, and IL-18 and IFN-gamma concentrations were higher in pleural fluid of patients with tuberculosis than in pleural fluid of patients with nontuberculous diseases. These findings demonstrate that IL-18 production by PBMC correlates with IFN-gamma production and effective immunity to tuberculosis, suggesting that IL-18 contributes to a protective type 1 cytokine response in persons with mycobacterial infection.

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Year:  2000        PMID： 10882602     DOI： 10.1086/315656

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  19 in total

1.  Profiles of IFN-gamma and its regulatory cytokines (IL-12, IL-18 and IL-10) in peripheral blood mononuclear cells from patients with multidrug-resistant tuberculosis.

Authors:  J-S Lee; C-H Song; C-H Kim; S-J Kong; M-H Shon; H-J Kim; J-K Park; T-H Paik; E-K Jo
Journal:  Clin Exp Immunol       Date:  2002-06       Impact factor: 4.330

2.  Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition.

Authors:  Francesca Gotsch; Roberto Romero; Tinnakorn Chaiworapongsa; Offer Erez; Edi Vaisbuch; Jimmy Espinoza; Juan Pedro Kusanovic; Pooja Mittal; Shali Mazaki-Tovi; Chong Jai Kim; Jung Sun Kim; Samuels Edwin; Chia-Ling Nhan-Chang; Neil Hamill; Laraa Friel; Nandor Gabor Than; Moshe Mazor; Bo Hyun Yoon; Sonia S Hassan
Journal:  J Matern Fetal Neonatal Med       Date:  2008-09

3.  Mycobacterium tuberculosis growth control by lung macrophages and CD8 cells from patient contacts.

Authors:  Claudia Carranza; Esmeralda Juárez; Martha Torres; Jerrold J Ellner; Eduardo Sada; Stephan K Schwander
Journal:  Am J Respir Crit Care Med       Date:  2005-10-06       Impact factor: 21.405

4.  Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis.

Authors:  Elżbieta Grześk; Sylwia Kołtan; Robert Dębski; Mariusz Wysocki; Marzena Gruszka; Małgorzata Kubicka; Andrzej Kołtan; Grzegorz Grześk; Sławomir Manysiak; Grażyna Odrowąż-Sypniewska
Journal:  Exp Ther Med       Date:  2010-07-20       Impact factor: 2.447

5.  Cytokines involved in interferon-gamma production by human macrophages.

Authors:  Cory M Robinson; Dawn O'Dee; Travis Hamilton; Gerard J Nau
Journal:  J Innate Immun       Date:  2009-10-10       Impact factor: 7.349

6.  Interleukin-21 Regulates Natural Killer Cell Responses During Mycobacterium tuberculosis Infection.

Authors:  Padmaja Paidipally; Deepak Tripathi; Abhinav Van; Rajesh Kumar Radhakrishnan; Rohan Dhiman; Sambasivan Venkatasubramanian; Kamakshi P Devalraju; Amy R Tvinnereim; Vijaya Lakshmi Valluri; Ramakrishna Vankayalapati
Journal:  J Infect Dis       Date:  2018-03-28       Impact factor: 5.226

7.  Increased pleural soluble fas ligand (sFasL) levels in tuberculosis pleurisy and its relation with T-helper type 1 cytokines.

Authors:  Ferah Budak; Esra Kunt Uzaslan; Sengül Cangür; Güher Göral; Haluk Barbaros Oral
Journal:  Lung       Date:  2008-07-29       Impact factor: 2.584

8.  Recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) expressing mouse IL-18 augments Th1 immunity and macrophage cytotoxicity.

Authors:  Y Luo; H Yamada; X Chen; A A Ryan; D P Evanoff; J A Triccas; M A O'Donnell
Journal:  Clin Exp Immunol       Date:  2004-07       Impact factor: 4.330

9.  Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18.

Authors:  Carolina Obregon; Donatus Dreher; Menno Kok; Laurence Cochand; Gitahi S Kiama; Laurent P Nicod
Journal:  Infect Immun       Date:  2003-08       Impact factor: 3.441

Review 10.  Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway.

Authors:  David A Lammas; E De Heer; J D Edgar; V Novelli; A Ben-Smith; R Baretto; P Drysdale; J Binch; C MacLennan; D S Kumararatne; S Panchalingam; T H M Ottenhoff; J-L Casanova; J F Emile
Journal:  Int J Exp Pathol       Date:  2002-02       Impact factor: 1.925
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