Literature DB >> 10882111

The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.

S Malik1, W Gu, W Wu, J Qin, R G Roeder.   

Abstract

PC2, the high-molecular weight constituent of the potent USA transcriptional coactivator fraction, was identified as a Mediator-like complex. Its composition resembles that of the TRAP/SMCC complex, but PC2 is distinguished by the prominent absence of the SRB10 and SRB11 kinase/cyclin pair, as well as several additional polypeptides. Furthermore, affinity-purified PC2, which lacks independent activity, acts in synergy with USA-derived coactivators PC3/topoisomerase I and PC4 to mediate the effects of a variety of activators (including VP16, the synthetic activator GAL4-AH, and the orphan nuclear receptor HNF4) and thus recapitulates partial USA coactivator function.

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Year:  2000        PMID： 10882111     DOI： 10.1016/s1097-2765(00)80254-3

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  47 in total

1.  Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s.

Authors:  Hwa Jin Baek; Sohail Malik; Jun Qin; Robert G Roeder
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

2.  TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA.

Authors:  Kristina M Johnson; Jin Wang; Andrea Smallwood; Charina Arayata; Michael Carey
Journal:  Genes Dev       Date:  2002-07-15       Impact factor: 11.361

Review 3.  Multi-protein complexes in eukaryotic gene transcription.

Authors:  Ernest Martinez
Journal:  Plant Mol Biol       Date:  2002-12       Impact factor: 4.076

4.  Coactivator cross-talk specifies transcriptional output.

Authors:  Michael T Marr; Yoh Isogai; Kevin J Wright; Robert Tjian
Journal:  Genes Dev       Date:  2006-06-01       Impact factor: 11.361

5.  Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator.

Authors:  Sohail Malik; Hwa Jin Baek; Weizhen Wu; Robert G Roeder
Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

Review 6.  The mediator of RNA polymerase II.

Authors:  Erik Blazek; Gerhard Mittler; Michael Meisterernst
Journal:  Chromosoma       Date:  2005-02-03       Impact factor: 4.316

7.  Identification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivator.

Authors:  Sohail Malik; María J Barrero; Tara Jones
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-02       Impact factor: 11.205

8.  Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development.

Authors:  Katrin Dürr; Jochen Holzschuh; Alida Filippi; Anne-Kathrin Ettl; Soojin Ryu; Iain T Shepherd; Wolfgang Driever
Journal:  Genetics       Date:  2006-04-02       Impact factor: 4.562

9.  TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.

Authors:  Camilla O Samuelsen; Vera Baraznenok; Olga Khorosjutina; Henrik Spahr; Thomas Kieselbach; Steen Holmberg; Claes M Gustafsson
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-08       Impact factor: 11.205

10.  A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.

Authors:  Gerhard Mittler; Thomas Stühler; Lisa Santolin; Thomas Uhlmann; Elisabeth Kremmer; F Lottspeich; Lucia Berti; Michael Meisterernst
Journal:  EMBO J       Date:  2003-12-15       Impact factor: 11.598
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