Literature DB >> 10882019

Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase.

D L Boger1, M A Labroli, T H Marsilje, Q Jin, M P Hedrick, S J Baker, J H Shim, S J Benkovic.   

Abstract

The synthesis and evaluation of a series of conformationally restricted analogues of 10-formyl-tetrahydrofolate as potential inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) or aminoimidazole carboxamide transformylase (AICAR Tfase) are reported.

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Year:  2000        PMID： 10882019     DOI： 10.1016/s0968-0896(00)00051-1

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes.

Authors:  Wanda Manieri; Molly E Moore; Matthew B Soellner; Pearl Tsang; Carol A Caperelli
Journal:  Biochemistry       Date:  2007-01-09       Impact factor: 3.162

2.  Localization of GAR transformylase in Escherichia coli and mammalian cells.

Authors:  L T Gooljarsingh; J Ramcharan; S Gilroy; S J Benkovic
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-29       Impact factor: 11.205

3.  Synthesis of dihydrouracils spiro-fused to pyrrolidines: druglike molecules based on the 2-arylethyl amine scaffold.

Authors:  Daniel Blanco-Ania; Carolina Valderas-Cortina; Pedro H H Hermkens; Leo A J M Sliedregt; Hans W Scheeren; Floris P J T Rutjes
Journal:  Molecules       Date:  2010-03-30       Impact factor: 4.411
  3 in total

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