Literature DB >> 10881901

Stability and sterility of recombinant tissue plasminogen activator at -30 degrees C.

J T Wiernikowski, M Crowther, C M Clase, A Ingram, M Andrew, A K Chan.   

Abstract

We assessed whether frozen recombinant tissue plasminogen activator (rt-PA) remains stable and sterile for up to 22 weeks at -30 degrees C. Our findings confirm that rt-PA is a cost-effective alternative to urokinase for restoring patency to occluded central venous catheters.

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Year:  2000        PMID: 10881901     DOI: 10.1016/S0140-6736(00)02411-9

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  6 in total

1.  Low-intensity adjusted-dose warfarin for the prevention of hemodialysis catheter failure: a randomized, controlled trial.

Authors:  Trevor J Wilkieson; Alistair J Ingram; Mark A Crowther; Steven D Soroka; Ryuta Nagai; Kailash K Jindal; Catherine M Clase
Journal:  Clin J Am Soc Nephrol       Date:  2011-04-14       Impact factor: 8.237

2.  Tissue plasminogen activator for blocked peritoneal dialysis catheters.

Authors:  R G Krishnan; N E Moghal
Journal:  Pediatr Nephrol       Date:  2005-10-27       Impact factor: 3.714

3.  Thrombolysis for restoration of patency to haemodialysis central venous catheters: a systematic review.

Authors:  C M Clase; M A Crowther; A J Ingram; C S Cinà
Journal:  J Thromb Thrombolysis       Date:  2001-04       Impact factor: 2.300

4.  Long-term stability of recombinant tissue plasminogen activator at -80 C.

Authors:  George J Shaw; Matthew Sperling; Jason M Meunier
Journal:  BMC Res Notes       Date:  2009-06-30

5.  Stability of Recombinant Tissue Plasminogen Activator at -30 °C over One Year.

Authors:  Abdulmalik Alkatheri
Journal:  Pharmaceuticals (Basel)       Date:  2013-01-02

6.  Spectrophotometric analysis of thrombolytic activity: SATA assay.

Authors:  Masumeh Zamanlu; Morteza Eskandani; Reza Mohammadian; Nazila Entekhabi; Mohammad Rafi; Mehdi Farhoudi
Journal:  Bioimpacts       Date:  2017-11-01
  6 in total

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