Literature DB >> 10881261

Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease.

A Tamaoka1, F Miyatake, S Matsuno, K Ishii, S Nagase, N Sahara, S Ono, H Mori, K Wakabayashi, S Tsuji, H Takahashi, S Shoji.   

Abstract

Thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation, were assayed in postmortem brain. Basal TBARS levels were increased and oxidative stimulation produced more TBARS in AD relative to control brains. In addition, apolipoprotein E isoforms showed differing antioxidant activities, with E2 > E3 > E4, suggesting that the lowest antioxidant activity of E4 could contribute to its association with AD.

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Year:  2000        PMID： 10881261     DOI： 10.1212/wnl.54.12.2319

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  16 in total

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