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Literature DB >> 10880339

Ascorbate oxidation is a prerequisite for its transport into rat liver microsomal vesicles.

M Csala¹, V Mile, A Benedetti, J Mandl, G Bánhegyi.

Abstract

Oxidation and uptake of ascorbate show similar time courses in rat liver microsomal vesicles: a rapid burst phase is followed by a slower process. Inhibitors of ascorbate oxidation (proadifen, econazole or quercetin) also effectively decreased the uptake of ascorbate. The results show that dehydroascorbate is the transport form of ascorbate at the membrane of the endoplasmic reticulum.

Entities: Chemical Disease Species

Mesh：

Substances：
Ascorbic Acid

Year: 2000 PMID： 10880339 PMCID： PMC1221163 DOI： 10.1042/0264-6021:3490413

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

16 in total

1. Superoxide-dependent oxidation of extracellular reducing agents by isolated neutrophils.

Authors: E L Thomas; D B Learn; M M Jefferson; W Weatherred
Journal: J Biol Chem Date: 1988-02-15 Impact factor: 5.157

2. Mammalian thioltransferase (glutaredoxin) and protein disulfide isomerase have dehydroascorbate reductase activity.

Authors: W W Wells; D P Xu; Y F Yang; P A Rocque
Journal: J Biol Chem Date: 1990-09-15 Impact factor: 5.157

3. Ascorbate-mediated electron transfer in protein thiol oxidation in the endoplasmic reticulum.

Authors: M Csala; L Braun; V Mile; T Kardon; A Szarka; P Kupcsulik; J Mandl; G Bánhegyi
Journal: FEBS Lett Date: 1999-11-05 Impact factor: 4.124

4. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid.

Authors: J C Vera; C I Rivas; J Fischbarg; D W Golde
Journal: Nature Date: 1993-07-01 Impact factor: 49.962

5. Inhibition of ascorbic acid transport in human neutrophils by glucose.

Authors: P Washko; M Levine
Journal: J Biol Chem Date: 1992-11-25 Impact factor: 5.157

Review 6. Transport of vitamin C in animal and human cells.

Authors: H Goldenberg; E Schweinzer
Journal: J Bioenerg Biomembr Date: 1994-08 Impact factor: 2.945

7. Guanosine 5'-triphosphate releases calcium from rat liver and guinea pig parotid gland endoplasmic reticulum independently of inositol 1,4,5-trisphosphate.

Authors: V Henne; H D Söling
Journal: FEBS Lett Date: 1986-07-07 Impact factor: 4.124

Ascorbate oxidation is a prerequisite for its transport into rat liver microsomal vesicles.

1. Superoxide-dependent oxidation of extracellular reducing agents by isolated neutrophils.

2. Mammalian thioltransferase (glutaredoxin) and protein disulfide isomerase have dehydroascorbate reductase activity.

3. Ascorbate-mediated electron transfer in protein thiol oxidation in the endoplasmic reticulum.

4. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid.

5. Inhibition of ascorbic acid transport in human neutrophils by glucose.

Review 6. Transport of vitamin C in animal and human cells.

7. Guanosine 5'-triphosphate releases calcium from rat liver and guinea pig parotid gland endoplasmic reticulum independently of inositol 1,4,5-trisphosphate.

8. Identification of L-ascorbic acid in secretion granules of the rat parotid gland.

9. Secretion of newly taken-up ascorbic acid by adrenomedullary chromaffin cells.

10. Exocrine secretion granules contain peptide amidation activity.

Review 1. The role of ascorbate in protein folding.

Review 2. Vitamin C: update on physiology and pharmacology.

3. Ascorbyl free radical and dehydroascorbate formation in rat liver endoplasmic reticulum.

Review 4. Participation of low molecular weight electron carriers in oxidative protein folding.