L Liu1, D Han, D Ren. 1. The Institute for Hepatology, Shanxi Medical University, Taiyuan 030001, China.
Abstract
OBJECTIVE: To study the effect of intestinal endotoxemia on pathogenesis of liver injury induced by thioacetamide (TAA). METHODS: Twenty-six male Wistar rats were divided into 4 groups, namely: normally control group (N), colectomy control group (C), colectomy+TAA group (C+T), TAA group (T). The changes in plasma biochemistry were measured. RESULTS: Plasma endotoxin levels were significantly higher in TAA group than normally control group. Plasma endotoxin levels in colectomy+TAA group were close to that of normally control group. Plasma ALT activity in colectomy+TAA group increased significantly compared with that of normal control group, but markedly lower than that in TAA group. Plasma endotoxin levels were positively correlated to ALT activity in T and C+T groups (r=0. 985, P<0.01). CONCLUSION: TAA itself has a deleterious effect to hepatic cells. It can also induce intestinal endotoxemia in which the liver injury is more inclined to occur and severe.
OBJECTIVE: To study the effect of intestinal endotoxemia on pathogenesis of liver injury induced by thioacetamide (TAA). METHODS: Twenty-six male Wistar rats were divided into 4 groups, namely: normally control group (N), colectomy control group (C), colectomy+TAA group (C+T), TAA group (T). The changes in plasma biochemistry were measured. RESULTS: Plasma endotoxin levels were significantly higher in TAA group than normally control group. Plasma endotoxin levels in colectomy+TAA group were close to that of normally control group. Plasma ALT activity in colectomy+TAA group increased significantly compared with that of normal control group, but markedly lower than that in TAA group. Plasma endotoxin levels were positively correlated to ALT activity in T and C+T groups (r=0. 985, P<0.01). CONCLUSION: TAA itself has a deleterious effect to hepatic cells. It can also induce intestinal endotoxemia in which the liver injury is more inclined to occur and severe.