BACKGROUND: ACE inhibitors have shown beneficial results in several studies after myocardial infarction (MI). However, these studies have shown conflicting results about the ideal starting time of the ACE inhibitors administration after MI and the importance of infarct size. OBJECTIVES: This study was designed to assess the long-term effects of lisinopril on mortality, cardiac function, and ventricular fibrosis after MI, in rats. METHODS: Lisinopril (20 mg/kg/day) was given on day 1 or 21 days after coronary occlusion in small or large infarctions. RESULTS: The mortality rate was reduced by 39 % in early treatment and 30 % in delayed treatment in comparison to the untreated rats. Early treatment reduced cardiac dysfunction in small MIs; however, delayed treatment did not. No statistical difference was observed among the groups for large MIs. No statistical difference was observed among the groups with large or small MIs on myocardial hydroxyproline concentration. CONCLUSIONS: Both early and delayed treatments with lisinopril increased survival. Treatment exerts no marked effects on fibrosis; early treatment has exerted beneficial influences on cardiac function whereas delayed treatment had no consistent effects. The protective effect of lisinopril is detectable only in small (< 40 % of LV) MIs.
BACKGROUND:ACE inhibitors have shown beneficial results in several studies after myocardial infarction (MI). However, these studies have shown conflicting results about the ideal starting time of the ACE inhibitors administration after MI and the importance of infarct size. OBJECTIVES: This study was designed to assess the long-term effects of lisinopril on mortality, cardiac function, and ventricular fibrosis after MI, in rats. METHODS:Lisinopril (20 mg/kg/day) was given on day 1 or 21 days after coronary occlusion in small or large infarctions. RESULTS: The mortality rate was reduced by 39 % in early treatment and 30 % in delayed treatment in comparison to the untreated rats. Early treatment reduced cardiac dysfunction in small MIs; however, delayed treatment did not. No statistical difference was observed among the groups for large MIs. No statistical difference was observed among the groups with large or small MIs on myocardial hydroxyproline concentration. CONCLUSIONS: Both early and delayed treatments with lisinopril increased survival. Treatment exerts no marked effects on fibrosis; early treatment has exerted beneficial influences on cardiac function whereas delayed treatment had no consistent effects. The protective effect of lisinopril is detectable only in small (< 40 % of LV) MIs.
Authors: Bertha F Polegato; Marcos F Minicucci; Paula S Azevedo; Andréa F Gonçalves; Aline F Lima; Paula F Martinez; Marina P Okoshi; Katashi Okoshi; Sergio A R Paiva; Leonardo A M Zornoff Journal: Arq Bras Cardiol Date: 2016-01-26 Impact factor: 2.000
Authors: Paula S Azevedo; Bertha F Polegato; Marcos F Minicucci; Stephan M Pio; Igor A Silva; Priscila P Santos; Katashi Okoshi; Sergio A R Paiva; Leonardo A M Zornoff Journal: Med Sci Monit Date: 2012-07
Authors: Daniella R Duarte; Marcos F Minicucci; Paula S Azevedo; Beatriz B Matsubara; Luiz S Matsubara; Ethel L Novelli; Sergio A R Paiva; Leonardo A M Zornoff Journal: Clinics (Sao Paulo) Date: 2009 Impact factor: 2.365
Authors: Marcos F Minicucci; Priscila P dos Santos; Bruna P M Rafacho; Andréa F Gonçalves; Lidiane P Ardisson; Diego F Batista; Paula S Azevedo; Bertha F Polegato; Katashi Okoshi; Elenize J Pereira; Sergio A R Paiva; Leonardo A M Zornoff Journal: Clinics (Sao Paulo) Date: 2013-10 Impact factor: 2.365
Authors: Marcos F Minicucci; Priscila P dos Santos; Bruna P M Rafacho; Andrea F Gonçalves; Renata A C Silva; Fernanda Chiuso-Minicucci; Paula S Azevedo; Bertha F Polegato; Katashi Okoshi; Elenize J Pereira; Sergio A R Paiva; Leonardo A M Zornoff Journal: PLoS One Date: 2013-09-30 Impact factor: 3.240