Literature DB >> 10879486

Apoptosis induced by the flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites in HL-60 cells.

S Ogata1, Y Miyake, K Yamamoto, K Okumura, H Taguchi.   

Abstract

The flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites, particularly eriodictyol, 3,4-dihydroxyhydrocinnamic acid, and phloroglucinol had the function of DNA fragmentation in HL-60 cells when analyzed by flow cytometry. An apoptotic DNA ladder and chromatin condensation were observed in HL-60 cells when treated with these compounds. The caspase inhibitor prevented DNA fragmentation. These compounds are anticipated to be useful for medical purposes.

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Year:  2000        PMID： 10879486     DOI： 10.1271/bbb.64.1075

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  6 in total

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4.  The protective effect of lemon fruit extract on histopathological changes induced in small intestines and pancreas of male mice by cyclophosphamide.

Authors:  Salwa Mohammed Quita; Samira Omar Balbaid
Journal:  Electron Physician       Date:  2015-10-19

5.  Established Human Cell Lines as Models to Study Anti-leukemic Effects of Flavonoids.

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6.  Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2/NQO-1/HO-1/NF-κB p65 proteins.

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  6 in total

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