Literature DB >> 10878861

Dynamical complexity and temporal plasticity in pancreatic beta-cells.

R Bertram1, A Sherman.   

Abstract

We discuss some of the biological and mathematical issues involved in understanding and modelling the bursting electrical activity in pancreatic beta-cells. These issues include single-cell versus islet behaviour, parameter heterogeneity, channel noise, the effects of hormones, neurotransmitters, and ions, and multiple slow biophysical processes. Some of the key experimental and modelling studies are described, and some of the major open questions are discussed.

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Year:  2000        PMID： 10878861

Source DB:  PubMed          Journal:  J Biosci        ISSN： 0250-5991            Impact factor:   1.826


  8 in total

Review 1.  Development, growth and maintenance of β-cell mass: models are also part of the story.

Authors:  Anmar Khadra; Santiago Schnell
Journal:  Mol Aspects Med       Date:  2015-02-23

2.  Capturing the bursting dynamics of a two-cell inhibitory network using a one-dimensional map.

Authors:  Victor Matveev; Amitabha Bose; Farzan Nadim
Journal:  J Comput Neurosci       Date:  2007-04-18       Impact factor: 1.621

3.  Slow variable dominance and phase resetting in phantom bursting.

Authors:  Margaret Watts; Joel Tabak; Charles Zimliki; Arthur Sherman; Richard Bertram
Journal:  J Theor Biol       Date:  2011-02-16       Impact factor: 2.691

Review 4.  The physiological role of β-cell heterogeneity in pancreatic islet function.

Authors:  Richard K P Benninger; Vira Kravets
Journal:  Nat Rev Endocrinol       Date:  2021-10-19       Impact factor: 43.330

Review 5.  Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications.

Authors:  E Sher; F Giovannini; A Codignola; M Passafaro; P Giorgi-Rossi; S Volsen; P Craig; A Davalli; P Carrera
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

6.  Bursting dynamics remarkably improve the performance of neural networks on liquid computing.

Authors:  Xiumin Li; Qing Chen; Fangzheng Xue
Journal:  Cogn Neurodyn       Date:  2016-04-28       Impact factor: 5.082

7.  Decreasing cx36 gap junction coupling compensates for overactive KATP channels to restore insulin secretion and prevent hyperglycemia in a mouse model of neonatal diabetes.

Authors:  Linda M Nguyen; Marina Pozzoli; Thomas H Hraha; Richard K P Benninger
Journal:  Diabetes       Date:  2014-01-23       Impact factor: 9.461

8.  The impact of mathematical modeling on the understanding of diabetes and related complications.

Authors:  I Ajmera; M Swat; C Laibe; N Le Novère; V Chelliah
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2013-07-10
  8 in total

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