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Literature DB >> 10878820

VHL takes HIF's breath away.

Abstract

Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2000 PMID： 10878820 DOI： 10.1038/35017129

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

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Cited

14 in total

1. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity.

Authors: Zaibo Li; Dakun Wang; Xi Na; Susan R Schoen; Edward M Messing; Guan Wu
Journal: EMBO J Date: 2003-04-15 Impact factor: 11.598

2. The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts.

Authors: C Wirbelauer; H Sutterlüty; M Blondel; M Gstaiger; M Peter; F Reymond; W Krek
Journal: EMBO J Date: 2000-10-16 Impact factor: 11.598

3. Inhibition of the HIF-1 Survival Pathway as a Strategy to Augment Photodynamic Therapy Efficacy.

Authors: Mark J de Keijzer; Daniel J de Klerk; Lianne R de Haan; Robert T van Kooten; Leonardo P Franchi; Lionel M Dias; Tony G Kleijn; Diederick J van Doorn; Michal Heger
Journal: Methods Mol Biol Date: 2022

Review 4. Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart.

Authors: Immanuel Turner; Fikru Belema-Bedada; Joshua Martindale; Dewayne Townsend; Wang Wang; Nathan Palpant; So-Chiro Yasuda; Matthew Barnabei; Ekaterina Fomicheva; Joseph M Metzger
Journal: J Cardiovasc Transl Res Date: 2008-12 Impact factor: 4.132

5. Double oxygen-sensing vector system for robust hypoxia/ischemia-regulated gene induction in cardiac muscle in vitro and in vivo.

Authors: Ekaterina V Fomicheva; Immanuel I Turner; Terri G Edwards; Janet Hoff; Eric Arden; Louis G D'Alecy; Joseph M Metzger
Journal: Mol Ther Date: 2008-06-24 Impact factor: 11.454

6. Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia.

Authors: Manik C Ghosh; De-Liang Zhang; Hayden Ollivierre; Michael A Eckhaus; Tracey A Rouault
Journal: J Clin Invest Date: 2018-02-26 Impact factor: 14.808

7. Putative Drivers of Aggressiveness in TCEB1-mutant Renal Cell Carcinoma: An Emerging Entity with Variable Clinical Course.

Authors: Renzo G DiNatale; Alexander N Gorelick; Vladimir Makarov; Kyle A Blum; Andrew W Silagy; Benjamin Freeman; Diego Chowell; Julian Marcon; Roy Mano; Alex Sanchez; Kyrollis Attalla; Stanley Weng; Martin Voss; Robert J Motzer; Paul Russo; Jonathan A Coleman; Victor E Reuter; Ying-Bei Chen; Timothy A Chan; Ed Reznik; Satish K Tickoo; A Ari Hakimi
Journal: Eur Urol Focus Date: 2019-12-06