Literature DB >> 10874880

Biclonal chronic lymphocytic leukemia.

E D Hsi1, G Hoeltge, R R Tubbs.   

Abstract

Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. We report 2 cases of biclonal CLL. Two elderly men were encountered with an absolute lymphocytosis consisting of the typical CD5+, CD19+, CD23+ B-cell population seen in CLL; however, immunoglobulin light chain restriction by flow cytometry was not apparent as B cells expressed kappa or lambda light chains without a clear monotypic population. Molecular genetic analysis of flow cytometry-sorted cells (kappa and lambda populations) revealed in both cases 2 monoclonal B-cell populations. The characterization of these cases and a review of the issues surrounding biclonal CLL are presented.

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Year:  2000        PMID： 10874880     DOI： 10.1309/V8AN-A2XP-7TDV-HR0T

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  7 in total

1.  Next-generation IgVH sequencing CLL-like monoclonal B-cell lymphocytosis reveals frequent oligoclonality and ongoing hypermutation.

Authors:  M Klinger; J Zheng; K S J Elenitoba-Johnson; S L Perkins; M Faham; D W Bahler
Journal:  Leukemia       Date:  2015-12-21       Impact factor: 11.528

2.  Persistent polyclonal B-cell lymphocytosis: extensively proliferated CD27+IgM+IgD+ memory B cells with a distinctive immunophenotype.

Authors:  M A Berkowska; C Grosserichter-Wagener; H J Adriaansen; D de Ridder; K P Mirani-Oostdijk; H J Agteresch; S Böttcher; A Orfao; J J M van Dongen; M C van Zelm
Journal:  Leukemia       Date:  2014-02-19       Impact factor: 11.528

3.  Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones.

Authors:  Karla Plevova; Hana Skuhrova Francova; Katerina Burckova; Yvona Brychtova; Michael Doubek; Sarka Pavlova; Jitka Malcikova; Jiri Mayer; Boris Tichy; Sarka Pospisilova
Journal:  Haematologica       Date:  2013-09-13       Impact factor: 9.941

4.  Clinical laboratory analysis of immunoglobulin heavy chain variable region genes for chronic lymphocytic leukemia prognosis.

Authors:  Philippe Szankasi; David W Bahler
Journal:  J Mol Diagn       Date:  2010-01-28       Impact factor: 5.568

5.  Multiparameter flow cytometry is necessary for detection, characterization and diagnostics of composite mature B-cell lymphoproliferative neoplasms.

Authors:  Sanja Perković; Sandra Bašić-Kinda; Igor Aurer; Ivo Ugrina; Antica Duletić-Načinović; Dominik Lozić; Drago Batinić
Journal:  Int J Hematol       Date:  2013-09-24       Impact factor: 2.490

6.  Single-Cell Analysis and Next-Generation Immuno-Sequencing Show That Multiple Clones Persist in Patients with Chronic Lymphocytic Leukemia.

Authors:  Jitra Kriangkum; Sarah N Motz; Tanner Mack; Sara Beiggi; Eva Baigorri; Hemalatha Kuppusamy; Andrew R Belch; James B Johnston; Linda M Pilarski
Journal:  PLoS One       Date:  2015-09-09       Impact factor: 3.240

7.  Network properties derived from deep sequencing of human B-cell receptor repertoires delineate B-cell populations.

Authors:  Rachael J M Bashford-Rogers; Anne L Palser; Brian J Huntly; Richard Rance; George S Vassiliou; George A Follows; Paul Kellam
Journal:  Genome Res       Date:  2013-06-06       Impact factor: 9.043
  7 in total

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